Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034006523> ?p ?o ?g. }
- W2034006523 endingPage "194" @default.
- W2034006523 startingPage "185" @default.
- W2034006523 abstract "Venous hypoxia has long been postulated as a potential cause of varicosity formation. This article aimed to review the development of this hypothesis, including evidence supporting and controversies surrounding it. Vein wall oxygenation is achieved by oxygen diffusing from luminal blood and vasa vasorum. The whole media of varicosities is oxygenated by vasa vasorum as compared to only the outer two-thirds of media of normal veins. There was no evidence that differences exist between oxygen content of blood from varicose and non-varicose veins, although the former demonstrated larger fluctuations with postural changes. Studies using cell culture and ex vivo explants demonstrated that hypoxia activated leucocytes and endothelium which released mediators regulating vein wall remodelling similar to those observed in varicosities. Venoactive drugs may improve venous oxygenation, and inhibit hypoxia activation of leucocytes and endothelium. The evidence for hypoxia as a causative factor in varicosities remains inconclusive, mainly due to heterogeneity and poor design of published in vivostudies. However, molecular studies have shown that hypoxia was able to cause inflammatory changes and vein wall remodelling similar to those observed in varicosities. Further studies are needed to improve our understanding of the role of hypoxia and help identify potential therapeutic targets." @default.
- W2034006523 created "2016-06-24" @default.
- W2034006523 creator A5007539244 @default.
- W2034006523 creator A5033505510 @default.
- W2034006523 creator A5064877301 @default.
- W2034006523 creator A5083597143 @default.
- W2034006523 creator A5090160276 @default.
- W2034006523 date "2010-11-23" @default.
- W2034006523 modified "2023-10-15" @default.
- W2034006523 title "Venous Hypoxia: A Poorly Studied Etiological Factor of Varicose Veins" @default.
- W2034006523 cites W111323999 @default.
- W2034006523 cites W113672205 @default.
- W2034006523 cites W116321794 @default.
- W2034006523 cites W1560585987 @default.
- W2034006523 cites W1601189145 @default.
- W2034006523 cites W1754314044 @default.
- W2034006523 cites W1968617385 @default.
- W2034006523 cites W1971045824 @default.
- W2034006523 cites W1973399144 @default.
- W2034006523 cites W1982754810 @default.
- W2034006523 cites W1984914572 @default.
- W2034006523 cites W1986589286 @default.
- W2034006523 cites W1987410170 @default.
- W2034006523 cites W1989477866 @default.
- W2034006523 cites W1994201273 @default.
- W2034006523 cites W1994572840 @default.
- W2034006523 cites W2002154995 @default.
- W2034006523 cites W2007425159 @default.
- W2034006523 cites W2010093496 @default.
- W2034006523 cites W2015291456 @default.
- W2034006523 cites W2019202175 @default.
- W2034006523 cites W2019932907 @default.
- W2034006523 cites W2020859442 @default.
- W2034006523 cites W2021319806 @default.
- W2034006523 cites W2024392440 @default.
- W2034006523 cites W2025019771 @default.
- W2034006523 cites W2025125263 @default.
- W2034006523 cites W2029570928 @default.
- W2034006523 cites W2031778182 @default.
- W2034006523 cites W2032194953 @default.
- W2034006523 cites W2039401607 @default.
- W2034006523 cites W2040619550 @default.
- W2034006523 cites W2050526169 @default.
- W2034006523 cites W2051042598 @default.
- W2034006523 cites W2055138880 @default.
- W2034006523 cites W2055439470 @default.
- W2034006523 cites W2056768480 @default.
- W2034006523 cites W2057237898 @default.
- W2034006523 cites W2058912647 @default.
- W2034006523 cites W2062235476 @default.
- W2034006523 cites W2063786552 @default.
- W2034006523 cites W2066870047 @default.
- W2034006523 cites W2068543541 @default.
- W2034006523 cites W2068647210 @default.
- W2034006523 cites W2080060134 @default.
- W2034006523 cites W2082034988 @default.
- W2034006523 cites W2082224498 @default.
- W2034006523 cites W2086817983 @default.
- W2034006523 cites W2096474421 @default.
- W2034006523 cites W2097233908 @default.
- W2034006523 cites W2099426430 @default.
- W2034006523 cites W2102581021 @default.
- W2034006523 cites W2109698524 @default.
- W2034006523 cites W2130611882 @default.
- W2034006523 cites W2145820622 @default.
- W2034006523 cites W2146382696 @default.
- W2034006523 cites W2164710413 @default.
- W2034006523 cites W2172236581 @default.
- W2034006523 cites W2241952037 @default.
- W2034006523 cites W2271852401 @default.
- W2034006523 cites W2324762289 @default.
- W2034006523 cites W233615326 @default.
- W2034006523 cites W2406337711 @default.
- W2034006523 cites W2407333729 @default.
- W2034006523 cites W2408757408 @default.
- W2034006523 cites W2411171743 @default.
- W2034006523 cites W2411188171 @default.
- W2034006523 cites W2412774949 @default.
- W2034006523 cites W2418407687 @default.
- W2034006523 cites W2421306898 @default.
- W2034006523 cites W2461659056 @default.
- W2034006523 cites W2474389385 @default.
- W2034006523 cites W2611133758 @default.
- W2034006523 cites W2730950519 @default.
- W2034006523 cites W30072045 @default.
- W2034006523 cites W2462830973 @default.
- W2034006523 doi "https://doi.org/10.1159/000320624" @default.
- W2034006523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21099225" @default.
- W2034006523 hasPublicationYear "2010" @default.
- W2034006523 type Work @default.
- W2034006523 sameAs 2034006523 @default.
- W2034006523 citedByCount "48" @default.
- W2034006523 countsByYear W20340065232012 @default.
- W2034006523 countsByYear W20340065232013 @default.
- W2034006523 countsByYear W20340065232014 @default.
- W2034006523 countsByYear W20340065232015 @default.
- W2034006523 countsByYear W20340065232016 @default.
- W2034006523 countsByYear W20340065232017 @default.