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- W2034006955 abstract "1 The effect of pentobarbitone on Ca2+ current (ICa), separated from other ionic currents was studied under voltage clamp using a suction pipette technique in Helix neurones. 2 Pentobarbitone depressed the maximal peak amplitude (MPA) of ICa in a concentration-dependent manner without shifting the current-voltage (I-V) relationships along the voltage axis. Increases in external Ca2+-concentration ([Ca2+]***o) overcame the inhibitory action of the agent on MPA. 3 Pentobarbitone markedly accelerated the decay phase of ICa which took a distinctly different time course from that of the control. The accelerating action of the agent on the decay phase of ICa was not overcome by increases in [Ca2+]o. In the presence of internal EGTA (20 mm), pentobarbitone also accelerated the decay of ICa. 4 Changes in pH of the external perfusing solution altered the potency of pentobarbitone in depressing MPA; in the presence of pentobarbitone (3 × 10−4 m) at pH of 7.0, 8.0 and 9.0, fractional inhibition was approx. 46%, 21% and 4%, respectively. 5 Internal application of pentobarbitone (10−4-10−3 m) inhibited MPA, but exerted no effect on the decay phase of ICa. 6 Pentobarbitone (10−4 m) markedly accelerated the decrease of MPA of ICa induced by repetitive stimuli applied at an interval of 150 ms, indicating a use-dependent depression of MPA. 7 Results provide evidence that pentobarbitone has a dual action on ICa, inhibiting MPA and accelerating the decay phase of ICa." @default.
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- W2034006955 date "1983-07-01" @default.
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- W2034006955 title "Accelerating effects of pentobarbitone on the inactivation process of the calcium current in Helix neurones" @default.
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- W2034006955 doi "https://doi.org/10.1111/j.1476-5381.1983.tb10001.x" @default.
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