FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034008402> ?p ?o ?g. }

• W2034008402 endingPage "10714" @default.
• W2034008402 startingPage "10710" @default.
• W2034008402 abstract "RNA fingerprinting using arbitrarily primed PCR (RAP) samples an RNA population and allows the detection of differentially expressed genes between two or more populations. This method was applied to mink lung epithelial cells, which respond to treatment with transforming growth factor beta (TGF-beta) by undergoing cell cycle arrest at or near the G1/S-phase boundary. The steady-state abundances of approximately 200 RNAs were surveyed, a few of which displayed differential regulation in response to TGF-beta 1. Three products were isolated, cloned, and sequenced. One differentially regulated RNA corresponded to cyclin A, a gene known to be required for the progression of mammalian fibroblasts through S phase. Northern blot analysis confirmed that the cyclin A mRNA steady-state abundance decreased dramatically in response to a 24-hr TGF-beta 1 treatment and also in response to cell cycle arrest caused by contact inhibition. A second RAP product corresponded to a previously unknown 7.5-kb mRNA, the level of which decreased dramatically in response to TGF-beta 1 treatment. Unlike the cyclin A mRNA, the abundance of this transcript did not decrease in response to growth arrest induced by contact inhibition. A third RAP product corresponded to the mRNA for osteonectin, an extracellular matrix protein. The abundance of this mRNA increased at least 2-fold during TGF-beta 1 treatment. This observation is consistent with other reports of increases in extracellular matrix proteins during TGF-beta treatment. RAP should be able to identify many of the genes that change in steady-state expression during the cell cycle." @default.
• W2034008402 created "2016-06-24" @default.
• W2034008402 creator A5009760367 @default.
• W2034008402 creator A5083233960 @default.
• W2034008402 creator A5083476377 @default.
• W2034008402 date "1993-11-15" @default.
• W2034008402 modified "2023-10-05" @default.
• W2034008402 title "RNA fingerprinting using arbitrarily primed PCR identifies differentially regulated RNAs in mink lung (Mv1Lu) cells growth arrested by transforming growth factor beta 1." @default.
• W2034008402 cites W1527058604 @default.
• W2034008402 cites W1544564404 @default.
• W2034008402 cites W1566096464 @default.
• W2034008402 cites W159450053 @default.
• W2034008402 cites W1659722210 @default.
• W2034008402 cites W183097839 @default.
• W2034008402 cites W1897751061 @default.
• W2034008402 cites W1963953102 @default.
• W2034008402 cites W1978368163 @default.
• W2034008402 cites W1979388953 @default.
• W2034008402 cites W1982933686 @default.
• W2034008402 cites W1984332535 @default.
• W2034008402 cites W1986937402 @default.
• W2034008402 cites W1999862535 @default.
• W2034008402 cites W2007443977 @default.
• W2034008402 cites W2014222675 @default.
• W2034008402 cites W2015446431 @default.
• W2034008402 cites W2027558915 @default.
• W2034008402 cites W2029344014 @default.
• W2034008402 cites W2029545106 @default.
• W2034008402 cites W2031938527 @default.
• W2034008402 cites W2036647778 @default.
• W2034008402 cites W2036817346 @default.
• W2034008402 cites W2037744654 @default.
• W2034008402 cites W2065480580 @default.
• W2034008402 cites W2072720547 @default.
• W2034008402 cites W2077326574 @default.
• W2034008402 cites W2084815044 @default.
• W2034008402 cites W2089921110 @default.
• W2034008402 cites W2092781810 @default.
• W2034008402 cites W2093611259 @default.
• W2034008402 cites W2099985524 @default.
• W2034008402 cites W2107359522 @default.
• W2034008402 cites W2136819827 @default.
• W2034008402 cites W2171114940 @default.
• W2034008402 cites W2283053703 @default.
• W2034008402 cites W2460785793 @default.
• W2034008402 cites W3024117005 @default.
• W2034008402 cites W4235005489 @default.
• W2034008402 doi "https://doi.org/10.1073/pnas.90.22.10710" @default.
• W2034008402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/47847" @default.
• W2034008402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8248163" @default.
• W2034008402 hasPublicationYear "1993" @default.
• W2034008402 type Work @default.
• W2034008402 sameAs 2034008402 @default.
• W2034008402 citedByCount "96" @default.
• W2034008402 countsByYear W20340084022016 @default.
• W2034008402 countsByYear W20340084022018 @default.
• W2034008402 crossrefType "journal-article" @default.
• W2034008402 hasAuthorship W2034008402A5009760367 @default.
• W2034008402 hasAuthorship W2034008402A5083233960 @default.
• W2034008402 hasAuthorship W2034008402A5083476377 @default.
• W2034008402 hasBestOaLocation W20340084021 @default.
• W2034008402 hasConcept C104317684 @default.
• W2034008402 hasConcept C105580179 @default.
• W2034008402 hasConcept C118131993 @default.
• W2034008402 hasConcept C150194340 @default.
• W2034008402 hasConcept C153911025 @default.
• W2034008402 hasConcept C177707886 @default.
• W2034008402 hasConcept C2778229498 @default.
• W2034008402 hasConcept C29537977 @default.
• W2034008402 hasConcept C54355233 @default.
• W2034008402 hasConcept C67705224 @default.
• W2034008402 hasConcept C86803240 @default.
• W2034008402 hasConcept C95444343 @default.
• W2034008402 hasConceptScore W2034008402C104317684 @default.
• W2034008402 hasConceptScore W2034008402C105580179 @default.
• W2034008402 hasConceptScore W2034008402C118131993 @default.
• W2034008402 hasConceptScore W2034008402C150194340 @default.
• W2034008402 hasConceptScore W2034008402C153911025 @default.
• W2034008402 hasConceptScore W2034008402C177707886 @default.
• W2034008402 hasConceptScore W2034008402C2778229498 @default.
• W2034008402 hasConceptScore W2034008402C29537977 @default.
• W2034008402 hasConceptScore W2034008402C54355233 @default.
• W2034008402 hasConceptScore W2034008402C67705224 @default.
• W2034008402 hasConceptScore W2034008402C86803240 @default.
• W2034008402 hasConceptScore W2034008402C95444343 @default.
• W2034008402 hasIssue "22" @default.
• W2034008402 hasLocation W20340084021 @default.
• W2034008402 hasLocation W20340084022 @default.
• W2034008402 hasLocation W20340084023 @default.
• W2034008402 hasLocation W20340084024 @default.
• W2034008402 hasOpenAccess W2034008402 @default.
• W2034008402 hasPrimaryLocation W20340084021 @default.
• W2034008402 hasRelatedWork W1972541767 @default.
• W2034008402 hasRelatedWork W1973552903 @default.
• W2034008402 hasRelatedWork W1981662335 @default.
• W2034008402 hasRelatedWork W1995115362 @default.
• W2034008402 hasRelatedWork W2009966535 @default.
• W2034008402 hasRelatedWork W2055485112 @default.

• next