Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034008510> ?p ?o ?g. }
- W2034008510 endingPage "175" @default.
- W2034008510 startingPage "175" @default.
- W2034008510 abstract "Neural stem cell sex dimorphism in aromatase (CYP19) expression: a basis for differential neural fate Jay Waldron1, Althea McCourty1, Laurent Lecanu1,21The Research Institute of the McGill University Health Centre, Montreal, Canada; 2Department of Medicine, McGill University, Quebec, CanadaPurpose: Neural stem cell (NSC) transplantation and pharmacologic activation of endogenous neurogenesis are two approaches that trigger a great deal of interest as brain repair strategies. However, the success rate of clinical attempts using stem cells to restore neurologic functions altered either after traumatic brain injury or as a consequence of neurodegenerative disease remains rather disappointing. This suggests that factors affecting the fate of grafted NSCs are largely understudied and remain to be characterized. We recently reported that aging differentially affects the neurogenic properties of male and female NSCs. Although the sex steroids androgens and estrogens participate in the regulation of neurogenesis, to our knowledge, research on how gender-based differences affect the capacity of NSCs to differentiate and condition their neural fate is lacking. In the present study, we explored further the role of cell sex as a determining factor of the neural fate followed by differentiating NSCs and its relationship with a potential differential expression of aromatase (CYP19), the testosterone-metabolizing enzyme.Results: Using NSCs isolated from the subventricular zone of three-month-old male and female Long-Evans rats and maintained as neurospheres, we showed that differentiation triggered by retinoic acid resulted in a neural phenotype that depends on cell sex. Differentiated male NSCs mainly expressed markers of neuronal fate, including ßIII-tubulin, microtubule associated protein 2, growth-associated protein 43, and doublecortin. In contrast, female NSCs essentially expressed the astrocyte marker glial fibrillary acidic protein. Quantification of the expression of aromatase showed a very low level of expression in undifferentiated female NSCs, whereas aromatase expression in male NSCs was 14-fold greater than the female level.Conclusion: Our results confirm our previous data that the neural phenotype acquired by differentiating NSCs largely depends on cell sex, and that differential expression of aromatase in undifferentiated NSCs might contribute to this sex-based dimorphism. Although still preliminary, our discovery may have clinical application in the development of future brain repair strategies.Keywords: neuroregenerative medicine, brain repair strategy, sex dimorphism, aromatase, adult stem cells" @default.
- W2034008510 created "2016-06-24" @default.
- W2034008510 creator A5009798947 @default.
- W2034008510 creator A5078915581 @default.
- W2034008510 creator A5089917584 @default.
- W2034008510 date "2010-11-01" @default.
- W2034008510 modified "2023-10-05" @default.
- W2034008510 title "Neural stem cell sex dimorphism in aromatase (CYP19) expression: a basis for differential neural fate" @default.
- W2034008510 cites W1785174879 @default.
- W2034008510 cites W1848517268 @default.
- W2034008510 cites W1976452465 @default.
- W2034008510 cites W1983905532 @default.
- W2034008510 cites W1995175293 @default.
- W2034008510 cites W2022579560 @default.
- W2034008510 cites W2031577596 @default.
- W2034008510 cites W2052435478 @default.
- W2034008510 cites W2073182617 @default.
- W2034008510 cites W2076955510 @default.
- W2034008510 cites W2078075583 @default.
- W2034008510 cites W2125507233 @default.
- W2034008510 cites W2125577585 @default.
- W2034008510 cites W2147963648 @default.
- W2034008510 cites W2157704923 @default.
- W2034008510 cites W2160966334 @default.
- W2034008510 cites W2162109306 @default.
- W2034008510 cites W2162184056 @default.
- W2034008510 cites W2163513779 @default.
- W2034008510 cites W2164771322 @default.
- W2034008510 cites W2323625512 @default.
- W2034008510 cites W2408075998 @default.
- W2034008510 cites W2414180555 @default.
- W2034008510 doi "https://doi.org/10.2147/sccaa.s15200" @default.
- W2034008510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3781747" @default.
- W2034008510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24198523" @default.
- W2034008510 hasPublicationYear "2010" @default.
- W2034008510 type Work @default.
- W2034008510 sameAs 2034008510 @default.
- W2034008510 citedByCount "14" @default.
- W2034008510 countsByYear W20340085102013 @default.
- W2034008510 countsByYear W20340085102014 @default.
- W2034008510 countsByYear W20340085102015 @default.
- W2034008510 countsByYear W20340085102017 @default.
- W2034008510 countsByYear W20340085102019 @default.
- W2034008510 countsByYear W20340085102021 @default.
- W2034008510 countsByYear W20340085102022 @default.
- W2034008510 countsByYear W20340085102023 @default.
- W2034008510 crossrefType "journal-article" @default.
- W2034008510 hasAuthorship W2034008510A5009798947 @default.
- W2034008510 hasAuthorship W2034008510A5078915581 @default.
- W2034008510 hasAuthorship W2034008510A5089917584 @default.
- W2034008510 hasBestOaLocation W20340085101 @default.
- W2034008510 hasConcept C104317684 @default.
- W2034008510 hasConcept C121608353 @default.
- W2034008510 hasConcept C136834591 @default.
- W2034008510 hasConcept C163952510 @default.
- W2034008510 hasConcept C169760540 @default.
- W2034008510 hasConcept C2776166826 @default.
- W2034008510 hasConcept C2777542384 @default.
- W2034008510 hasConcept C28328180 @default.
- W2034008510 hasConcept C4746552 @default.
- W2034008510 hasConcept C530470458 @default.
- W2034008510 hasConcept C54355233 @default.
- W2034008510 hasConcept C86339819 @default.
- W2034008510 hasConcept C86803240 @default.
- W2034008510 hasConcept C95444343 @default.
- W2034008510 hasConceptScore W2034008510C104317684 @default.
- W2034008510 hasConceptScore W2034008510C121608353 @default.
- W2034008510 hasConceptScore W2034008510C136834591 @default.
- W2034008510 hasConceptScore W2034008510C163952510 @default.
- W2034008510 hasConceptScore W2034008510C169760540 @default.
- W2034008510 hasConceptScore W2034008510C2776166826 @default.
- W2034008510 hasConceptScore W2034008510C2777542384 @default.
- W2034008510 hasConceptScore W2034008510C28328180 @default.
- W2034008510 hasConceptScore W2034008510C4746552 @default.
- W2034008510 hasConceptScore W2034008510C530470458 @default.
- W2034008510 hasConceptScore W2034008510C54355233 @default.
- W2034008510 hasConceptScore W2034008510C86339819 @default.
- W2034008510 hasConceptScore W2034008510C86803240 @default.
- W2034008510 hasConceptScore W2034008510C95444343 @default.
- W2034008510 hasLocation W20340085101 @default.
- W2034008510 hasLocation W20340085102 @default.
- W2034008510 hasLocation W20340085103 @default.
- W2034008510 hasLocation W20340085104 @default.
- W2034008510 hasLocation W20340085105 @default.
- W2034008510 hasOpenAccess W2034008510 @default.
- W2034008510 hasPrimaryLocation W20340085101 @default.
- W2034008510 hasRelatedWork W1521652786 @default.
- W2034008510 hasRelatedWork W2028948697 @default.
- W2034008510 hasRelatedWork W2104934532 @default.
- W2034008510 hasRelatedWork W2130946516 @default.
- W2034008510 hasRelatedWork W2135046848 @default.
- W2034008510 hasRelatedWork W233354604 @default.
- W2034008510 hasRelatedWork W2914367266 @default.
- W2034008510 hasRelatedWork W2952830265 @default.
- W2034008510 hasRelatedWork W4244950130 @default.
- W2034008510 hasRelatedWork W69835883 @default.
- W2034008510 isParatext "false" @default.
- W2034008510 isRetracted "false" @default.