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• W2034008536 startingPage "3287" @default.
• W2034008536 abstract "A class of bisarylimidazole derivatives are identified as potent inhibitors of the enzyme fatty acid amide hydrolase (FAAH). Compound 17 (IC50 = 2 nM) dose-dependently (0.1–10 mg/kg, iv) potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models of persistent (formalin test) and neuropathic (Chung model) pain. Compound 17 (20 mg/kg, iv) demonstrates activity in the formalin test that is comparable to morphine (3 mg/kg, iv), and is dose-dependently inhibited by the CB1 antagonist SR141716A. In the Chung model, compound 17 shows antineuropathic effects similar to high-dose (100 mg/kg) gabapentin. FAAH inhibition shows potential utility for the clinical treatment of persistent and neuropathic pain." @default.
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• W2034008536 date "2007-06-01" @default.
• W2034008536 modified "2023-09-23" @default.
• W2034008536 title "Novel inhibitors of fatty acid amide hydrolase" @default.
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• W2034008536 doi "https://doi.org/10.1016/j.bmcl.2007.04.009" @default.
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