Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034008864> ?p ?o ?g. }
- W2034008864 endingPage "11020" @default.
- W2034008864 startingPage "11015" @default.
- W2034008864 abstract "The transcription factor E2F1 is known to regulate cell proliferation and has been thought to modulate tumorigenesis via this mechanism alone. Here we show that mice deficient in E2F1 exhibit enhanced angiogenesis. The proangiogenic phenotype in E2F1 deficiency is the result of overproduction of vascular endothelial growth factor (VEGF) and is prevented by VEGF blockade. Under hypoxic conditions, E2F1 down-regulates the expression of VEGF promoter activity by associating with p53 and specifically down-regulating expression of VEGF but not other hypoxia-inducible genes, suggesting a promoter structure context-dependent regulation mechanism. We found that the minimum VEGF promoter mediating transcriptional repression by E2F1 features an E2F1- binding site with four Sp-1 sites in close proximity. These data disclose an unexpected function of endogenous E2F1: regulation of angiogenic activity via p53-dependent transcriptional control of VEGF expression." @default.
- W2034008864 created "2016-06-24" @default.
- W2034008864 creator A5002798288 @default.
- W2034008864 creator A5011960490 @default.
- W2034008864 creator A5022443137 @default.
- W2034008864 creator A5024396516 @default.
- W2034008864 creator A5024835739 @default.
- W2034008864 creator A5026267300 @default.
- W2034008864 creator A5031305752 @default.
- W2034008864 creator A5036876525 @default.
- W2034008864 creator A5037949855 @default.
- W2034008864 creator A5042848023 @default.
- W2034008864 creator A5044788727 @default.
- W2034008864 creator A5053065728 @default.
- W2034008864 creator A5065764983 @default.
- W2034008864 creator A5065979761 @default.
- W2034008864 creator A5075376877 @default.
- W2034008864 creator A5084445039 @default.
- W2034008864 creator A5089473181 @default.
- W2034008864 date "2006-07-18" @default.
- W2034008864 modified "2023-10-03" @default.
- W2034008864 title "Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF" @default.
- W2034008864 cites W1501165752 @default.
- W2034008864 cites W1516709117 @default.
- W2034008864 cites W1517579686 @default.
- W2034008864 cites W1522060570 @default.
- W2034008864 cites W1580865462 @default.
- W2034008864 cites W1587947784 @default.
- W2034008864 cites W1598900543 @default.
- W2034008864 cites W161287260 @default.
- W2034008864 cites W1783580437 @default.
- W2034008864 cites W1965080968 @default.
- W2034008864 cites W1969399504 @default.
- W2034008864 cites W1975900149 @default.
- W2034008864 cites W1978139448 @default.
- W2034008864 cites W1980022529 @default.
- W2034008864 cites W1980759602 @default.
- W2034008864 cites W1991847137 @default.
- W2034008864 cites W1992346069 @default.
- W2034008864 cites W1994211285 @default.
- W2034008864 cites W2001446552 @default.
- W2034008864 cites W2001627329 @default.
- W2034008864 cites W2007499397 @default.
- W2034008864 cites W2008301561 @default.
- W2034008864 cites W2009214757 @default.
- W2034008864 cites W2009974292 @default.
- W2034008864 cites W2014552752 @default.
- W2034008864 cites W2018363066 @default.
- W2034008864 cites W2028999918 @default.
- W2034008864 cites W2032948236 @default.
- W2034008864 cites W2033791403 @default.
- W2034008864 cites W2036021417 @default.
- W2034008864 cites W2038291224 @default.
- W2034008864 cites W2040588918 @default.
- W2034008864 cites W2054728198 @default.
- W2034008864 cites W2061621687 @default.
- W2034008864 cites W2066125587 @default.
- W2034008864 cites W2079729042 @default.
- W2034008864 cites W2081697027 @default.
- W2034008864 cites W2084212386 @default.
- W2034008864 cites W2091799227 @default.
- W2034008864 cites W2095908158 @default.
- W2034008864 cites W2098470595 @default.
- W2034008864 cites W2099791897 @default.
- W2034008864 cites W2099960599 @default.
- W2034008864 cites W2106066126 @default.
- W2034008864 cites W2115272028 @default.
- W2034008864 cites W2125538315 @default.
- W2034008864 cites W2126490563 @default.
- W2034008864 cites W2129949097 @default.
- W2034008864 cites W2135994263 @default.
- W2034008864 cites W2143778153 @default.
- W2034008864 cites W2145639716 @default.
- W2034008864 cites W2157735460 @default.
- W2034008864 cites W2167710900 @default.
- W2034008864 cites W2171562255 @default.
- W2034008864 cites W2172253185 @default.
- W2034008864 cites W2188274605 @default.
- W2034008864 cites W2330982233 @default.
- W2034008864 cites W4246575879 @default.
- W2034008864 cites W4294718043 @default.
- W2034008864 cites W935429972 @default.
- W2034008864 doi "https://doi.org/10.1073/pnas.0509533103" @default.
- W2034008864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1544166" @default.
- W2034008864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16835303" @default.
- W2034008864 hasPublicationYear "2006" @default.
- W2034008864 type Work @default.
- W2034008864 sameAs 2034008864 @default.
- W2034008864 citedByCount "98" @default.
- W2034008864 countsByYear W20340088642012 @default.
- W2034008864 countsByYear W20340088642013 @default.
- W2034008864 countsByYear W20340088642014 @default.
- W2034008864 countsByYear W20340088642015 @default.
- W2034008864 countsByYear W20340088642016 @default.
- W2034008864 countsByYear W20340088642017 @default.
- W2034008864 countsByYear W20340088642018 @default.
- W2034008864 countsByYear W20340088642019 @default.
- W2034008864 countsByYear W20340088642020 @default.