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• W2034009330 abstract "We propose a new adaptive procedure for dose-finding in clinical trials with combination of two drugs when both efficacy and toxicity responses are available. We model the distribution of this bivariate binary endpoint using the bivariate probit model. The analytic formulae for the Fisher information matrix are obtained, that form the basis for derivation of the locally optimal, minimax, Bayesian, and adaptive designs in the framework of optimal design theory." @default.
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• W2034009330 date "2008-02-01" @default.
• W2034009330 modified "2023-09-30" @default.
• W2034009330 title "Adaptive designs for selecting drug combinations based on efficacy–toxicity response" @default.
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• W2034009330 doi "https://doi.org/10.1016/j.jspi.2007.06.017" @default.
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