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• W2034011015 abstract "Abstract The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work 1 explored one possible underlying mechanism called permutation‐by‐duplication, which produces special forms of motif rearrangements called circular permutations. Permutation‐by‐duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins 1 and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence. BioEssays 28: 973–978, 2006. © 2006 Wiley Periodicals, Inc." @default.
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• W2034011015 date "2006-09-22" @default.
• W2034011015 modified "2023-10-16" @default.
• W2034011015 title "Duplication, divergence and formation of novel protein topologies" @default.
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• W2034011015 doi "https://doi.org/10.1002/bies.20474" @default.
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