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• W2034011645 abstract "Summary This prospective study was designed to evaluate whether early changes in actin‐free G c‐globulin levels were associated with complications and outcomes and to identify factors associated with persistent low actin‐free G c‐globulin levels in acute liver failure ( ALF ). Thirty‐two consecutive ALF patients admitted from O ctober 2011 to D ecember 2012 were followed up until death or complete recovery. All had serum actin‐free G c‐globulin estimation at admission and at day three or expiry. Logistic regression analysis was performed to identify independent predictors of mortality. A receiver operating characteristic curve analysis was also performed. Nonsurvivors had significantly lower median actin‐free G c‐globulin levels than survivors (87.32 vs 180 mg/L; P < 0.001). A receiver operating characteristic curve analysis revealed an area under curve ( AUC ) of 0.771 and showed that serum actin‐free G c‐globulin level of ≤124 mg/L would predict mortality with 92% sensitivity and 71.4% specificity. Patients with lower serum actin‐free G c‐globulin levels and decreasing trend in serum actin‐free G c‐globulin levels were found to have more mortality and developed more complications. Logistic regression analysis showed that serum actin‐free G c‐globulin, total leucocyte count and serum creatinine at admission were independent predictors of mortality. Incorporating these variables, a score predicting mortality risk at admission was derived. The scoring system was compared to MELD score and K ing's C ollege C riteria as individual predictor of mortality. Serum actin‐free G c‐globulin level at presentation is predictive of outcome and can be used for risk stratification. Its persistent low‐level predicts mortality and is correlated with various complications." @default.
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• W2034011645 date "2014-04-28" @default.
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• W2034011645 title "Predictive value of serum actin-free Gc-globulin for complications and outcome in acute liver failure" @default.
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• W2034011645 doi "https://doi.org/10.1111/jvh.12259" @default.
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