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- W2034011920 abstract "Based on molecular docking analysis of complexes between flavone and the c-myc G-quadruplex, we designed and screened 30 flavone derivatives containing various side chains that could potentially form interactions with the G-quadruplex grooves. As a proof-of-concept, the highest-scoring flavone derivatives containing cationic pyridinium side chains were synthesized and their interactions with the c-myc G-quadruplex were examined using a PCR-stop assay. The stabilizing effects of the flavone derivatives were found to be selective towards the c-myc G-quadruplex over other biologically relevant G-quadruplex structures, such as the human telomeric sequence (HTS). The interaction between the most potent compound of the series and the c-myc G-quadruplex was examined in depth using UV–Vis titration, molecular modeling and CD spectroscopy. Our results suggest that in addition to stabilizing the c-myc G-quadruplex, the flavone derivatives were capable of inducing the formation of the G-quadruplex structure even in the absence of monovalent cations. The flavone derivatives were found to be potent inhibitors of c-myc promoters within the cellular environment and displayed promising cytotoxic behavior against human cancer cell lines." @default.
- W2034011920 created "2016-06-24" @default.
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- W2034011920 date "2013-01-01" @default.
- W2034011920 modified "2023-09-30" @default.
- W2034011920 title "Structure-based design of flavone derivatives as c-myc oncogene down-regulators" @default.
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- W2034011920 doi "https://doi.org/10.1016/j.ejps.2012.10.010" @default.
- W2034011920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23127826" @default.
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