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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034013862> ?p ?o ?g. }

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• W2034013862 abstract "Novel NR2B antagonists with an amide tether were found by an approach to avoid pharmacophoric similarity to dofetilide. Structure-activity relationship investigation led to N-[cis-4-hydroxy-4-(5-hydroxypyridin-2-yl)cyclohexyl]-3-henylpropanamide as an orally active NR2B-subtype selective N-methyl-D-aspartate (NMDA) receptor antagonist with very weak HERG (human ether-a-go-go related gene) binding (IC(50)> 30 microM). This compound exhibited potent in vivo anti-allodynic activity in the mouse partial sciatic nerve ligation (PSL) model (minimum effective dose=10 mg/kg, po)." @default.
• W2034013862 created "2016-06-24" @default.
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• W2034013862 date "2007-10-01" @default.
• W2034013862 modified "2023-09-27" @default.
• W2034013862 title "Discovery of novel and orally active NR2B-selective N-methyl-d-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity" @default.
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• W2034013862 doi "https://doi.org/10.1016/j.bmcl.2007.08.039" @default.
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