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- W2034015235 endingPage "310" @default.
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- W2034015235 abstract "Heterogeneous expression of the epidermal growth factor receptor (EGFR) in glioblastoma poses an important challenge for the effective use of EGFR-targeted therapies. In this Opinion article, Furnariet al. highlight the possible mechanisms underlying EGFR heterogeneity, and the importance in understanding these mechanisms to improve treatment outcome in glioblastoma. As tumours evolve, the daughter cells of the initiating cell often become molecularly heterogeneous and develop different functional properties and therapeutic vulnerabilities. In glioblastoma (GBM), a lethal form of brain cancer, the heterogeneous expression of the epidermal growth factor receptor (EGFR) poses a substantial challenge for the effective use of EGFR-targeted therapies. Understanding the mechanisms that cause EGFR heterogeneity in GBM should provide better insights into how they, and possibly other amplified receptor tyrosine kinases, affect cellular signalling, metabolism and drug resistance." @default.
- W2034015235 created "2016-06-24" @default.
- W2034015235 creator A5042065032 @default.
- W2034015235 creator A5063511816 @default.
- W2034015235 creator A5072507966 @default.
- W2034015235 creator A5080403474 @default.
- W2034015235 date "2015-04-09" @default.
- W2034015235 modified "2023-10-18" @default.
- W2034015235 title "Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma" @default.
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