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• W2034015730 abstract "The rapid intravenous infusion of fructose produces a transient increase in plasma urate concentration, as well as an increase in the urinary excretion of oxypurines and uric acid. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte phosphoribosylpyrophosphate (PP-ribose-P) and ribose-5-phosphate concentration, and no detectable change in erythrocyte ATP concentration. Although pretreatment with allopurinol prevents the hyperuricemic effect of fructose, the increase in plasma lactate is not modified and the increase in urinary oxypurine excretion is enhanced. These results are consistent with the hypothesis, based on previous studies in the rat, that fructose-induced hyperuricemia in man results from an increased degradation of purine ribonucleotides." @default.
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• W2034015730 date "1972-08-01" @default.
• W2034015730 modified "2023-10-14" @default.
• W2034015730 title "Studies on the mechanism of fructose-induced hyperuricemia in man" @default.
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• W2034015730 doi "https://doi.org/10.1016/0026-0495(72)90120-5" @default.
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