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- W2034016242 abstract "The interaction of two potential photobiological agents, 3H-naphtho[2,1-b]pyran-3-one (I) and 9-(ω-diethylaminopropyloxy)-3H-naphtho[2,1-b]pyran-3-one (II), with DNA has been investigated using spectrophotometric, hydrodynamic and chiroptical techniques. The DNA-binding parameters were estimated for both compounds, by the neighbour exclusion model, as a function of temperature and ionic strength. From the temperature dependence of the complex formation constants, the binding process appears to be exothermic, with Van't Hoff enthalpies of the order of −50 kJ mol−1. Unlike compound I, the interaction of DNA with compound II, bearing a charged side chain, is dramatically affected by salt concentration. Ion release and binding free energy corrected for free energy of counterion release were estimated quantitatively. Lack of preference for different binding sites was observed for both compounds, using DNA from various sources. Increase in melting temperature, viscometric measurements and circular dichroism results indicate substantial modifications in DNA structural properties upon binding of compounds I and II. Our data suggest that benzocoumarins retain the ability of intercalating into the polynucleotide double helix with the same orientation proposed for the photobiologically active furocoumarins." @default.
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- W2034016242 date "1984-08-01" @default.
- W2034016242 modified "2023-09-25" @default.
- W2034016242 title "Interaction of deoxyribonucleic acid with potential photobiological agents: a physicochemical investigation" @default.
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- W2034016242 doi "https://doi.org/10.1016/0141-8130(84)90032-1" @default.
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