FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034016963> ?p ?o ?g. }

• W2034016963 endingPage "e169" @default.
• W2034016963 startingPage "e164" @default.
• W2034016963 abstract "The HIV Prevention Trials Network (HPTN) 046 trial evaluated the efficacy of extended infant nevirapine (NVP) administration for prevention of HIV transmission through breastfeeding. Infants received daily NVP up to 6 weeks of age. HIV-uninfected infants (the intent-to-treat group) received daily NVP or placebo up to 6 months of age. We analyzed emergence of NVP resistance in infants who acquired HIV infection despite prophylaxis.HIV genotyping was performed using the ViroSeq HIV Genotyping System. Medians and proportions were used to summarize data. Two-sided Fisher exact tests were used to evaluate associations between categorical variables.NVP resistance was detected in 12 (92.3%) of 13 infants who were HIV-infected by 6 weeks and in 7 (28%) of 25 infants who were HIV-uninfected at 6 weeks and HIV-infected at 6 months of age (6/8 = 75% in the NVP arm, 1/17 = 5.9% in the placebo arm, P = 0.001). Among those 25 infants, 4 had mothers who initiated an antiretroviral treatment regimen by 6 months postpartum. In all 4 cases, the treatment regimen included a non-nucleoside reverse transcriptase inhibitor (NVP or efavirenz). NVP resistance was detected in all 4 of those infants by 6 months of age (4/4 = 100%). In contrast, only 3 (14.2%) of the remaining 21 HIV-infected infants whose mothers did not initiate antiretroviral treatment developed NVP resistance (P = 0.003).Extended NVP prophylaxis significantly increased the risk of NVP resistance in infants who acquired HIV infection after 6 weeks of age. Treatment of maternal HIV infection was also associated with emergence of NVP resistance in HIV-infected, breastfed infants." @default.
• W2034016963 created "2016-06-24" @default.
• W2034016963 creator A5000225884 @default.
• W2034016963 creator A5003476888 @default.
• W2034016963 creator A5005087563 @default.
• W2034016963 creator A5017238174 @default.
• W2034016963 creator A5021982451 @default.
• W2034016963 creator A5028350605 @default.
• W2034016963 creator A5034556592 @default.
• W2034016963 creator A5044641475 @default.
• W2034016963 creator A5064954217 @default.
• W2034016963 creator A5076484464 @default.
• W2034016963 creator A5081294489 @default.
• W2034016963 creator A5084006354 @default.
• W2034016963 creator A5086432190 @default.
• W2034016963 creator A5091507463 @default.
• W2034016963 date "2013-04-01" @default.
• W2034016963 modified "2023-10-06" @default.
• W2034016963 title "Impact of Maternal and Infant Antiretroviral Drug Regimens on Drug Resistance in HIV-infected Breastfeeding Infants" @default.
• W2034016963 cites W1969073576 @default.
• W2034016963 cites W1987037885 @default.
• W2034016963 cites W1989496797 @default.
• W2034016963 cites W2038183880 @default.
• W2034016963 cites W2047555579 @default.
• W2034016963 cites W2067788204 @default.
• W2034016963 cites W2072612814 @default.
• W2034016963 cites W2088688302 @default.
• W2034016963 cites W2096244211 @default.
• W2034016963 cites W2112601356 @default.
• W2034016963 cites W2118166920 @default.
• W2034016963 cites W2126184004 @default.
• W2034016963 cites W2127256232 @default.
• W2034016963 cites W2127583738 @default.
• W2034016963 cites W2130978107 @default.
• W2034016963 cites W2134746895 @default.
• W2034016963 cites W2162919143 @default.
• W2034016963 cites W2164057082 @default.
• W2034016963 cites W2165826479 @default.
• W2034016963 cites W2167590829 @default.
• W2034016963 cites W2169221951 @default.
• W2034016963 doi "https://doi.org/10.1097/inf.0b013e31827f44ee" @default.
• W2034016963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3826537" @default.
• W2034016963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23249916" @default.
• W2034016963 hasPublicationYear "2013" @default.
• W2034016963 type Work @default.
• W2034016963 sameAs 2034016963 @default.
• W2034016963 citedByCount "28" @default.
• W2034016963 countsByYear W20340169632013 @default.
• W2034016963 countsByYear W20340169632014 @default.
• W2034016963 countsByYear W20340169632015 @default.
• W2034016963 countsByYear W20340169632016 @default.
• W2034016963 countsByYear W20340169632017 @default.
• W2034016963 countsByYear W20340169632018 @default.
• W2034016963 countsByYear W20340169632019 @default.
• W2034016963 countsByYear W20340169632020 @default.
• W2034016963 countsByYear W20340169632021 @default.
• W2034016963 countsByYear W20340169632022 @default.
• W2034016963 countsByYear W20340169632023 @default.
• W2034016963 crossrefType "journal-article" @default.
• W2034016963 hasAuthorship W2034016963A5000225884 @default.
• W2034016963 hasAuthorship W2034016963A5003476888 @default.
• W2034016963 hasAuthorship W2034016963A5005087563 @default.
• W2034016963 hasAuthorship W2034016963A5017238174 @default.
• W2034016963 hasAuthorship W2034016963A5021982451 @default.
• W2034016963 hasAuthorship W2034016963A5028350605 @default.
• W2034016963 hasAuthorship W2034016963A5034556592 @default.
• W2034016963 hasAuthorship W2034016963A5044641475 @default.
• W2034016963 hasAuthorship W2034016963A5064954217 @default.
• W2034016963 hasAuthorship W2034016963A5076484464 @default.
• W2034016963 hasAuthorship W2034016963A5081294489 @default.
• W2034016963 hasAuthorship W2034016963A5084006354 @default.
• W2034016963 hasAuthorship W2034016963A5086432190 @default.
• W2034016963 hasAuthorship W2034016963A5091507463 @default.
• W2034016963 hasBestOaLocation W20340169632 @default.
• W2034016963 hasConcept C114851261 @default.
• W2034016963 hasConcept C126322002 @default.
• W2034016963 hasConcept C142462285 @default.
• W2034016963 hasConcept C142724271 @default.
• W2034016963 hasConcept C187212893 @default.
• W2034016963 hasConcept C203014093 @default.
• W2034016963 hasConcept C204787440 @default.
• W2034016963 hasConcept C2522874641 @default.
• W2034016963 hasConcept C27081682 @default.
• W2034016963 hasConcept C2776283161 @default.
• W2034016963 hasConcept C2777869810 @default.
• W2034016963 hasConcept C2779130552 @default.
• W2034016963 hasConcept C2780593183 @default.
• W2034016963 hasConcept C2781413609 @default.
• W2034016963 hasConcept C2781432083 @default.
• W2034016963 hasConcept C2993143319 @default.
• W2034016963 hasConcept C3013748606 @default.
• W2034016963 hasConcept C71924100 @default.
• W2034016963 hasConcept C86803240 @default.
• W2034016963 hasConcept C89423630 @default.
• W2034016963 hasConceptScore W2034016963C114851261 @default.
• W2034016963 hasConceptScore W2034016963C126322002 @default.
• W2034016963 hasConceptScore W2034016963C142462285 @default.
• W2034016963 hasConceptScore W2034016963C142724271 @default.

• next