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• W2034016996 endingPage "1340" @default.
• W2034016996 startingPage "1334" @default.
• W2034016996 abstract "Atherosclerosis includes a series of cellular and molecular responses characteristic of an inflammatory disease. We provide evidence that cupric-ion-oxidized LDL (CuLDL) or endothelial cell-oxidized LDL (ELDL) induced the activation by Tyr-phosphorylation of JAK2, one of the Janus kinase involved upstream of STATs in the JAK/STAT pathway of cytokine transduction. Oxidized LDL (OxLDL) also initiated STAT1 and STAT3 Tyr-phosphorylation and translocation to the nucleus, with a more marked effect for the extensively modified CuLDL. Genistein, a nonspecific Tyr-kinase inhibitor, and AG490, a specific inhibitor of JAKs, markedly prevented the CuLDL-induced enhancement of STAT1 and STAT3 Tyr-phosphorylation and DNA-binding activity, suggesting that JAKs are the main kinases involved in STATs’ activation by oxidized LDL. In addition, the lipid extract of CuLDL increased the intracellular levels of lipid peroxidation products and the Tyr-phosphorylation of JAK2, STAT1, and STAT3, whereas the antioxidant vitamin E prevented all these effects. These results demonstrate that OxLDL induces the activation by Tyr-phosphorylation of JAK2, STAT1, and STAT3 by generation of an intracellular oxidative stress by means of its lipid peroxidation products, and thus include JAK2 within the range of oxidative stress-activated kinases." @default.
• W2034016996 created "2016-06-24" @default.
• W2034016996 creator A5002227682 @default.
• W2034016996 creator A5038733910 @default.
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• W2034016996 date "2001-12-01" @default.
• W2034016996 modified "2023-10-07" @default.
• W2034016996 title "Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein" @default.
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• W2034016996 doi "https://doi.org/10.1016/s0891-5849(01)00649-9" @default.
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