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• W2034017564 startingPage "e89296" @default.
• W2034017564 abstract "It is becoming increasingly important to address the long-term effects of exposure to simulated microgravity as the potential for space tourism and life in space become prominent topics amongst the World’s governments. There are several studies examining the effects of exposure to simulated microgravity on various developmental systems and in various organisms; however, few examine the effects beyond the juvenile stages. In this study, we expose zebrafish embryos to simulated microgravity starting at key stages associated with cranial neural crest cell migration. We then analyzed the skeletons of adult fish. Gross observations and morphometric analyses show that exposure to simulated microgravity results in stunted growth, reduced ossification and severe distortion of some skeletal elements. Additionally, we investigated the effects on the juvenile skull and body pigmentation. This study determines for the first time the long-term effects of embryonic exposure to simulated microgravity on the developing skull and highlights the importance of studies investigating the effects of altered gravitational forces." @default.
• W2034017564 created "2016-06-24" @default.
• W2034017564 creator A5039641843 @default.
• W2034017564 creator A5052417223 @default.
• W2034017564 date "2014-02-20" @default.
• W2034017564 modified "2023-09-27" @default.
• W2034017564 title "An Assessment of the Long-Term Effects of Simulated Microgravity on Cranial Neural Crest Cells in Zebrafish Embryos with a Focus on the Adult Skeleton" @default.
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• W2034017564 doi "https://doi.org/10.1371/journal.pone.0089296" @default.
• W2034017564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3930699" @default.
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• W2034017564 hasPublicationYear "2014" @default.
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