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- W2034017782 endingPage "157" @default.
- W2034017782 startingPage "147" @default.
- W2034017782 abstract "Cell chemotaxis requires the acquisition and maintenance of both spatial and functional asymmetry between initially equivalent cell parts. In leukocytes one becomes the leading edge and the other, the rear edge or uropod. The acquisition of this cell polarity is controlled by an array of chemoattractants, including those of the chemokine family. We propose that chemokine receptor activation in highly organized lipid raft domains is a major determinant for the correct localization of the signaling pathways leading to the cell asymmetries required for migration. The lateral organization imposed by membrane raft microdomains is discussed in the context of other chemokine receptor activities, such as its role as a human immunodeficiency virus (HIV) coreceptor." @default.
- W2034017782 created "2016-06-24" @default.
- W2034017782 creator A5030159349 @default.
- W2034017782 creator A5051411928 @default.
- W2034017782 creator A5051712299 @default.
- W2034017782 creator A5063642954 @default.
- W2034017782 creator A5077587097 @default.
- W2034017782 creator A5091675075 @default.
- W2034017782 date "2001-04-01" @default.
- W2034017782 modified "2023-10-18" @default.
- W2034017782 title "Membrane raft microdomains in chemokine receptor function" @default.
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- W2034017782 doi "https://doi.org/10.1006/smim.2000.0306" @default.
- W2034017782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11308298" @default.