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- W2034017832 abstract "Understanding the contribution of cerebellar dysfunction to complex neurological diseases such as autism spectrum disorders (ASD) is an ongoing topic of investigation. In a recent paper, Tsai et al. (Nature 488:647-651, 2012) used a powerful combination of conditional mouse genetics, electrophysiology, behavioral tests, and pharmacological manipulations to address the role of Tuberous sclerosis complex 1 (Tsc1) in Purkinje cells and cerebellar function. The authors make the staggering discovery that morphological and electrophysiological defects in Purkinje cells are linked to system-wide ASD-like behavioral deficits. In this journal club, I discuss the major findings of this paper and critically assess the implications of this seminal work." @default.
- W2034017832 created "2016-06-24" @default.
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- W2034017832 date "2013-05-25" @default.
- W2034017832 modified "2023-09-26" @default.
- W2034017832 title "Defining the Role of Cerebellar Purkinje Cells in Autism Spectrum Disorders" @default.
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- W2034017832 doi "https://doi.org/10.1007/s12311-013-0490-y" @default.
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