Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034017972> ?p ?o ?g. }
- W2034017972 endingPage "47" @default.
- W2034017972 startingPage "43" @default.
- W2034017972 abstract "We attempted to investigate the safety and efficacy of alternative weekly topotecan dosing in a heavily pretreated Taiwanese population with recurrent epithelial ovarian cancer (EOC) and primary peritoneal carcinoma (PPC). We retrospectively reviewed the medical records of patients with recurrent EOC and PPC who had been treated with weekly topotecan between November 2008 and May 2012. Topotecan was given at a dose of 2.75–4 mg/m2 via a 30-minute intravenous (IV) infusion on Days 1, 8, and 15 of a 28-day cycle until disease progression or unacceptable toxicity occurred. Thirty-two patients were identified and 24 (75%) of them had received at least two previous regimens of chemotherapy; the median number of treatment courses was seven. The main toxicities (Grades 3 and 4) were anemia in seven (21.9%), neutropenia in six (18.8%), and thrombocytopenia in two patients (6.2%). No deaths were attributable to the therapy. Overall, seven patients (21.9%) showed a partial response (PR), while seven patients (21.9%) with stable disease (SD) were observed. Furthermore, we found a favorable response and toxicity profile in patients who received the lowest dose intensity (2.75 mg/m2). The median progression-free survival (PFS) and overall survival (OS) were 3 months [95% confidence interval (CI) 2.7–3.2] and 20 months (95% CI 11.1–28.9), respectively. Topotecan administered as a weekly dosage (2.75–4 mg/m2) seems to be a tolerable regimen with modest activity in a Taiwanese population. Although the lower dose schedule showed a higher response with a better toxicity profile, further studies with more cases are needed to confirm this finding." @default.
- W2034017972 created "2016-06-24" @default.
- W2034017972 creator A5013129858 @default.
- W2034017972 creator A5015703643 @default.
- W2034017972 creator A5018987054 @default.
- W2034017972 creator A5045591857 @default.
- W2034017972 creator A5061029781 @default.
- W2034017972 creator A5066963121 @default.
- W2034017972 creator A5076626440 @default.
- W2034017972 date "2015-02-01" @default.
- W2034017972 modified "2023-10-16" @default.
- W2034017972 title "The use of weekly topotecan in the treatment of heavily pretreated recurrent epithelial ovarian and primary peritoneal cancer: The Kaohsiung Chang Gung experience" @default.
- W2034017972 cites W1606254941 @default.
- W2034017972 cites W1965379690 @default.
- W2034017972 cites W1970025718 @default.
- W2034017972 cites W1972856753 @default.
- W2034017972 cites W1978453679 @default.
- W2034017972 cites W1987409084 @default.
- W2034017972 cites W1988151075 @default.
- W2034017972 cites W1993632733 @default.
- W2034017972 cites W2002710053 @default.
- W2034017972 cites W2006350851 @default.
- W2034017972 cites W2019087543 @default.
- W2034017972 cites W2019607817 @default.
- W2034017972 cites W2028192904 @default.
- W2034017972 cites W2031019593 @default.
- W2034017972 cites W2034572897 @default.
- W2034017972 cites W2039195665 @default.
- W2034017972 cites W2043103956 @default.
- W2034017972 cites W2052824735 @default.
- W2034017972 cites W2056278185 @default.
- W2034017972 cites W2061681410 @default.
- W2034017972 cites W2089082327 @default.
- W2034017972 cites W2090453433 @default.
- W2034017972 cites W2105704419 @default.
- W2034017972 cites W2124058261 @default.
- W2034017972 cites W2162104840 @default.
- W2034017972 cites W2328501245 @default.
- W2034017972 doi "https://doi.org/10.1016/j.tjog.2014.11.005" @default.
- W2034017972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25675918" @default.
- W2034017972 hasPublicationYear "2015" @default.
- W2034017972 type Work @default.
- W2034017972 sameAs 2034017972 @default.
- W2034017972 citedByCount "3" @default.
- W2034017972 countsByYear W20340179722015 @default.
- W2034017972 countsByYear W20340179722016 @default.
- W2034017972 countsByYear W20340179722017 @default.
- W2034017972 crossrefType "journal-article" @default.
- W2034017972 hasAuthorship W2034017972A5013129858 @default.
- W2034017972 hasAuthorship W2034017972A5015703643 @default.
- W2034017972 hasAuthorship W2034017972A5018987054 @default.
- W2034017972 hasAuthorship W2034017972A5045591857 @default.
- W2034017972 hasAuthorship W2034017972A5061029781 @default.
- W2034017972 hasAuthorship W2034017972A5066963121 @default.
- W2034017972 hasAuthorship W2034017972A5076626440 @default.
- W2034017972 hasBestOaLocation W20340179721 @default.
- W2034017972 hasConcept C121608353 @default.
- W2034017972 hasConcept C126322002 @default.
- W2034017972 hasConcept C141071460 @default.
- W2034017972 hasConcept C143998085 @default.
- W2034017972 hasConcept C2776694085 @default.
- W2034017972 hasConcept C2777063308 @default.
- W2034017972 hasConcept C2777288759 @default.
- W2034017972 hasConcept C2778248108 @default.
- W2034017972 hasConcept C2780427987 @default.
- W2034017972 hasConcept C2781209748 @default.
- W2034017972 hasConcept C2781413609 @default.
- W2034017972 hasConcept C2908647359 @default.
- W2034017972 hasConcept C29730261 @default.
- W2034017972 hasConcept C71924100 @default.
- W2034017972 hasConcept C90924648 @default.
- W2034017972 hasConcept C99454951 @default.
- W2034017972 hasConceptScore W2034017972C121608353 @default.
- W2034017972 hasConceptScore W2034017972C126322002 @default.
- W2034017972 hasConceptScore W2034017972C141071460 @default.
- W2034017972 hasConceptScore W2034017972C143998085 @default.
- W2034017972 hasConceptScore W2034017972C2776694085 @default.
- W2034017972 hasConceptScore W2034017972C2777063308 @default.
- W2034017972 hasConceptScore W2034017972C2777288759 @default.
- W2034017972 hasConceptScore W2034017972C2778248108 @default.
- W2034017972 hasConceptScore W2034017972C2780427987 @default.
- W2034017972 hasConceptScore W2034017972C2781209748 @default.
- W2034017972 hasConceptScore W2034017972C2781413609 @default.
- W2034017972 hasConceptScore W2034017972C2908647359 @default.
- W2034017972 hasConceptScore W2034017972C29730261 @default.
- W2034017972 hasConceptScore W2034017972C71924100 @default.
- W2034017972 hasConceptScore W2034017972C90924648 @default.
- W2034017972 hasConceptScore W2034017972C99454951 @default.
- W2034017972 hasIssue "1" @default.
- W2034017972 hasLocation W20340179721 @default.
- W2034017972 hasLocation W20340179722 @default.
- W2034017972 hasOpenAccess W2034017972 @default.
- W2034017972 hasPrimaryLocation W20340179721 @default.
- W2034017972 hasRelatedWork W1812462844 @default.
- W2034017972 hasRelatedWork W1969833561 @default.
- W2034017972 hasRelatedWork W1981260623 @default.
- W2034017972 hasRelatedWork W2076024279 @default.
- W2034017972 hasRelatedWork W2081775820 @default.