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• W2034042693 abstract "Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and neurotransmitters. Here evidence for the control of gating by calcium was found in electrophysiological records of single, L-type calcium channels in heart cells. Conditional open probability analysis revealed that calcium entry during the opening of a single channel produces alterations in gating transition rates that evolve over the course of hundreds of milliseconds. Such alteration of calcium-channel gating by entry of a favored permeant ion provides a mechanism for the short-term modulation of single-ion channels." @default.
• W2034042693 created "2016-06-24" @default.
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• W2034042693 date "1990-12-21" @default.
• W2034042693 modified "2023-09-26" @default.
• W2034042693 title "Calcium-Sensitive Inactivation in the Gating of Single Calcium Channels" @default.
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• W2034042693 doi "https://doi.org/10.1126/science.2176745" @default.
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