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- W2034047010 startingPage "942" @default.
- W2034047010 abstract "The successful implementation of photodynamic therapy (PDT)-based regimens depends on an improved understanding of the dosimetric and biological factors that govern therapeutic variability. Here, the kinetics of tumor destruction and regrowth are characterized by systematically varying benzoporphyrin derivative (BPD)-light combinations to achieve fixed PDT doses (M × J cm(-2)). Three endpoints were used to evaluate treatment response: (1) Viability evaluated every 24 h for 5 days post-PDT; (2) Photobleaching assessed immediately post-PDT; and (3) Caspase-3 activation determined 24 h post-PDT. The specific BPD-light parameters used to construct a given PDT dose significantly impact not only acute cytotoxic efficacy, but also treatment durability. For each dose, PDT with 0.25 μM BPD produces the most significant and sustained reduction in normalized viability compared to 1 and 10 μM BPD. Percent photobleaching correlates with normalized viability for a range of PDT doses achieved within BPD concentrations. To produce a cytotoxic response with 10 μM BPD that is comparable to 0.25 and 1 μM BPD a reduction in irradiance from 150 to 0.5 mW cm(-2) is required. Activated caspase-3 does not correlate with normalized viability. The parameter-dependent durability of outcomes within fixed PDT doses provides opportunities for treatment customization and improved therapeutic planning." @default.
- W2034047010 created "2016-06-24" @default.
- W2034047010 creator A5004594328 @default.
- W2034047010 creator A5004672009 @default.
- W2034047010 creator A5007170985 @default.
- W2034047010 creator A5012583049 @default.
- W2034047010 creator A5023103421 @default.
- W2034047010 creator A5058184923 @default.
- W2034047010 creator A5060309212 @default.
- W2034047010 creator A5064683888 @default.
- W2034047010 creator A5080481089 @default.
- W2034047010 date "2013-04-04" @default.
- W2034047010 modified "2023-10-18" @default.
- W2034047010 title "PDT Dose Parameters Impact Tumoricidal Durability and Cell Death Pathways in a 3D Ovarian Cancer Model" @default.
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