FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034047229> ?p ?o ?g. }

• W2034047229 endingPage "1783" @default.
• W2034047229 startingPage "1775" @default.
• W2034047229 abstract "In this study, we examined the biological functions of Gab1 in erythropoietin receptor (EPOR)-mediated signaling in vivo. Knockdown of Gab1 by the introduction of the Gab1 siRNA expression vector into F-36P human erythroleukemia (F-36P-Gab1-siRNA) cells resulted in a reduction of cell proliferation and survival in response to EPO. EPO-induced activation of Erk1/2 but not of Akt was significantly suppressed in F-36P-Gab1-siRNA cells compared with mock-transfected F-36P cells. The co-immunoprecipitation experiments revealed an EPO-enhanced association of Gab1 with the Grb2-SOS1 complex and SHP-2 in F-36P cells. A selective inhibitor of phosphatidylinositol 3-kinase (PI3K) LY294002 and short interfering RNA (siRNA) duplexes targeting the p85 regulatory subunit of PI3K (p85-siRNA) independently suppressed tyrosine phosphorylation of Gab1; its association with Grb2, SHP-2 and p85; and the activation of Erk in EPO-treated F-36P cells. LY294002 inhibited EPO-induced tyrosine phosphorylation of Gab1 and its association with Grb2 in human primary EPO-sensitive erythroid cells. The co-immunoprecipitation experiments using the Jak inhibitor AG490 or siRNA duplexes targeting Jak2 and in vitro binding experiments demonstrated that Jak2 regulated Gab1-mediated Erk activation through tyrosine phosphorylation of Gab1. Taken together, these results suggest that Gab1 couples PI3K-mediated EPO signals with the Ras/Erk pathway and that Gab1 plays an important role in EPOR-mediated signal transduction involved in the proliferation and survival of erythroid cells." @default.
• W2034047229 created "2016-06-24" @default.
• W2034047229 creator A5000955182 @default.
• W2034047229 creator A5013531050 @default.
• W2034047229 creator A5017832747 @default.
• W2034047229 creator A5032053910 @default.
• W2034047229 creator A5066917025 @default.
• W2034047229 creator A5078152417 @default.
• W2034047229 creator A5081895201 @default.
• W2034047229 creator A5084106741 @default.
• W2034047229 creator A5091145269 @default.
• W2034047229 date "2009-12-01" @default.
• W2034047229 modified "2023-09-25" @default.
• W2034047229 title "Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells" @default.
• W2034047229 cites W1479869774 @default.
• W2034047229 cites W1529003705 @default.
• W2034047229 cites W1599602125 @default.
• W2034047229 cites W1846395924 @default.
• W2034047229 cites W1886472157 @default.
• W2034047229 cites W1914550558 @default.
• W2034047229 cites W1967463427 @default.
• W2034047229 cites W1971372076 @default.
• W2034047229 cites W1985057592 @default.
• W2034047229 cites W1985439299 @default.
• W2034047229 cites W1986021138 @default.
• W2034047229 cites W1988795257 @default.
• W2034047229 cites W1994598048 @default.
• W2034047229 cites W1999695125 @default.
• W2034047229 cites W2000894919 @default.
• W2034047229 cites W2001675065 @default.
• W2034047229 cites W2009857536 @default.
• W2034047229 cites W2017141883 @default.
• W2034047229 cites W2025541527 @default.
• W2034047229 cites W2036274324 @default.
• W2034047229 cites W2039975110 @default.
• W2034047229 cites W2041603493 @default.
• W2034047229 cites W2051066066 @default.
• W2034047229 cites W2059668731 @default.
• W2034047229 cites W2065082115 @default.
• W2034047229 cites W2075515257 @default.
• W2034047229 cites W2076153728 @default.
• W2034047229 cites W2080822958 @default.
• W2034047229 cites W2086819383 @default.
• W2034047229 cites W2088363096 @default.
• W2034047229 cites W2095861062 @default.
• W2034047229 cites W2125543544 @default.
• W2034047229 cites W2136475585 @default.
• W2034047229 cites W2143948360 @default.
• W2034047229 cites W2145448769 @default.
• W2034047229 cites W2154817329 @default.
• W2034047229 cites W2162014238 @default.
• W2034047229 cites W2245431203 @default.
• W2034047229 cites W2278285517 @default.
• W2034047229 cites W2317478958 @default.
• W2034047229 cites W2318679023 @default.
• W2034047229 cites W2327877875 @default.
• W2034047229 cites W2343705780 @default.
• W2034047229 doi "https://doi.org/10.1016/j.cellsig.2009.07.013" @default.
• W2034047229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19665053" @default.
• W2034047229 hasPublicationYear "2009" @default.
• W2034047229 type Work @default.
• W2034047229 sameAs 2034047229 @default.
• W2034047229 citedByCount "14" @default.
• W2034047229 countsByYear W20340472292012 @default.
• W2034047229 countsByYear W20340472292014 @default.
• W2034047229 countsByYear W20340472292017 @default.
• W2034047229 countsByYear W20340472292018 @default.
• W2034047229 countsByYear W20340472292019 @default.
• W2034047229 countsByYear W20340472292020 @default.
• W2034047229 countsByYear W20340472292021 @default.
• W2034047229 countsByYear W20340472292022 @default.
• W2034047229 countsByYear W20340472292023 @default.
• W2034047229 crossrefType "journal-article" @default.
• W2034047229 hasAuthorship W2034047229A5000955182 @default.
• W2034047229 hasAuthorship W2034047229A5013531050 @default.
• W2034047229 hasAuthorship W2034047229A5017832747 @default.
• W2034047229 hasAuthorship W2034047229A5032053910 @default.
• W2034047229 hasAuthorship W2034047229A5066917025 @default.
• W2034047229 hasAuthorship W2034047229A5078152417 @default.
• W2034047229 hasAuthorship W2034047229A5081895201 @default.
• W2034047229 hasAuthorship W2034047229A5084106741 @default.
• W2034047229 hasAuthorship W2034047229A5091145269 @default.
• W2034047229 hasConcept C11960822 @default.
• W2034047229 hasConcept C153911025 @default.
• W2034047229 hasConcept C22615655 @default.
• W2034047229 hasConcept C2776912716 @default.
• W2034047229 hasConcept C2777553839 @default.
• W2034047229 hasConcept C31102739 @default.
• W2034047229 hasConcept C502942594 @default.
• W2034047229 hasConcept C54009773 @default.
• W2034047229 hasConcept C54355233 @default.
• W2034047229 hasConcept C55493867 @default.
• W2034047229 hasConcept C57074206 @default.
• W2034047229 hasConcept C62112901 @default.
• W2034047229 hasConcept C62478195 @default.
• W2034047229 hasConcept C81885089 @default.
• W2034047229 hasConcept C86554907 @default.
• W2034047229 hasConcept C86803240 @default.

• next