Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034057930> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2034057930 endingPage "184" @default.
- W2034057930 startingPage "184" @default.
- W2034057930 abstract "Resistin is an adipokine secreted from adipose tissue, which is likely involved in the development of obesity and insulin resistance via its interaction with other organs, as well as affecting adipose tissue function. The impact of resistin treatment on lipolysis and adiponectin secretion in human visceral adipose tissue is currently unknown. Mesenteric adipose tissue samples were obtained from 14 male subjects [age 54 ± 6 yr, body mass index (BMI) 23.59 ± 0.44 kg/m2] undergoing abdominal surgeries. Adipose tissues were cultured and treated with resistin (100 ng/mL, 24 h) in the absence or presence of different signaling inhibitors: H89 (1 μM), PD98059 (25 μM) and SB201290 (20 μM) for glycerol and non-esterified fatty acid (NEFA) measurement. Adiponectin level from media at 24 h was also measured via ELISA. Adipose tissue minces after resistin incubation (100 ng/mL, 24 h) were also collected for further Western blotting analysis.Resistin resulted in significant induction of glycerol (3.62 ± 0.57 vs. 5.30 ± 1.11 mmol/L/g tissue, p < 0.05) and NEFA (5.99 ± 1.06 vs. 8.48 ± 1.57 mmol/L/g tissue, p < 0.05) release at 24 h. H89 and PD98059 partially inhibited resistin induced glycerol and NEFA release, while SB201290 has no such effect. Resistin induced the phosphorylation of p-HSL at serine 563, PKA at ~ 62 kDa and ERK1/2 as measured by Western blotting. Resistin led to significant reduction of the secretion of adiponectin (38.16 ± 10.43 vs. 21.81 ± 4.21 ng/mL/g tissue, p < 0.05). Our current findings implicate that resistin might play a significant role in obesity related pathologies in various tissues via its effect on adipose tissue function." @default.
- W2034057930 created "2016-06-24" @default.
- W2034057930 creator A5003534549 @default.
- W2034057930 creator A5004752701 @default.
- W2034057930 creator A5058919377 @default.
- W2034057930 creator A5070300449 @default.
- W2034057930 date "2007-06-01" @default.
- W2034057930 modified "2023-09-25" @default.
- W2034057930 title "PO21-685 THE COST OF OBESITY IN CROATIA" @default.
- W2034057930 doi "https://doi.org/10.1016/s1567-5688(07)71695-1" @default.
- W2034057930 hasPublicationYear "2007" @default.
- W2034057930 type Work @default.
- W2034057930 sameAs 2034057930 @default.
- W2034057930 citedByCount "1" @default.
- W2034057930 crossrefType "journal-article" @default.
- W2034057930 hasAuthorship W2034057930A5003534549 @default.
- W2034057930 hasAuthorship W2034057930A5004752701 @default.
- W2034057930 hasAuthorship W2034057930A5058919377 @default.
- W2034057930 hasAuthorship W2034057930A5070300449 @default.
- W2034057930 hasConcept C126322002 @default.
- W2034057930 hasConcept C134018914 @default.
- W2034057930 hasConcept C140985366 @default.
- W2034057930 hasConcept C142462285 @default.
- W2034057930 hasConcept C171089720 @default.
- W2034057930 hasConcept C185592680 @default.
- W2034057930 hasConcept C194832188 @default.
- W2034057930 hasConcept C203014093 @default.
- W2034057930 hasConcept C2776175234 @default.
- W2034057930 hasConcept C2776782570 @default.
- W2034057930 hasConcept C2777391703 @default.
- W2034057930 hasConcept C2779306644 @default.
- W2034057930 hasConcept C2779760629 @default.
- W2034057930 hasConcept C2779772378 @default.
- W2034057930 hasConcept C2780941825 @default.
- W2034057930 hasConcept C2993143319 @default.
- W2034057930 hasConcept C3013748606 @default.
- W2034057930 hasConcept C511355011 @default.
- W2034057930 hasConcept C71924100 @default.
- W2034057930 hasConceptScore W2034057930C126322002 @default.
- W2034057930 hasConceptScore W2034057930C134018914 @default.
- W2034057930 hasConceptScore W2034057930C140985366 @default.
- W2034057930 hasConceptScore W2034057930C142462285 @default.
- W2034057930 hasConceptScore W2034057930C171089720 @default.
- W2034057930 hasConceptScore W2034057930C185592680 @default.
- W2034057930 hasConceptScore W2034057930C194832188 @default.
- W2034057930 hasConceptScore W2034057930C203014093 @default.
- W2034057930 hasConceptScore W2034057930C2776175234 @default.
- W2034057930 hasConceptScore W2034057930C2776782570 @default.
- W2034057930 hasConceptScore W2034057930C2777391703 @default.
- W2034057930 hasConceptScore W2034057930C2779306644 @default.
- W2034057930 hasConceptScore W2034057930C2779760629 @default.
- W2034057930 hasConceptScore W2034057930C2779772378 @default.
- W2034057930 hasConceptScore W2034057930C2780941825 @default.
- W2034057930 hasConceptScore W2034057930C2993143319 @default.
- W2034057930 hasConceptScore W2034057930C3013748606 @default.
- W2034057930 hasConceptScore W2034057930C511355011 @default.
- W2034057930 hasConceptScore W2034057930C71924100 @default.
- W2034057930 hasIssue "1" @default.
- W2034057930 hasLocation W20340579301 @default.
- W2034057930 hasOpenAccess W2034057930 @default.
- W2034057930 hasPrimaryLocation W20340579301 @default.
- W2034057930 hasRelatedWork W1985960242 @default.
- W2034057930 hasRelatedWork W1989361659 @default.
- W2034057930 hasRelatedWork W2005837673 @default.
- W2034057930 hasRelatedWork W2016467848 @default.
- W2034057930 hasRelatedWork W2022264206 @default.
- W2034057930 hasRelatedWork W2027098794 @default.
- W2034057930 hasRelatedWork W2048359366 @default.
- W2034057930 hasRelatedWork W2048572539 @default.
- W2034057930 hasRelatedWork W2048596524 @default.
- W2034057930 hasRelatedWork W2055437256 @default.
- W2034057930 hasVolume "8" @default.
- W2034057930 isParatext "false" @default.
- W2034057930 isRetracted "false" @default.
- W2034057930 magId "2034057930" @default.
- W2034057930 workType "article" @default.