FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034068913> ?p ?o ?g. }

• W2034068913 endingPage "3177" @default.
• W2034068913 startingPage "3168" @default.
• W2034068913 abstract "CD4 is a transmembrane glycoprotein fundamental for cell-mediated immunity. Its action as a T cell co-receptor increases the avidity of association between a T cell and an antigen-presenting cell by interacting with portions of the complex between MHC class II and TR molecules. In this paper we report the cDNA cloning, expression and structural analysis of a CD4 homologue from sea bass (Dicentrarchus labrax). The sea bass CD4 cDNA consists of 2071 bp that translates in one reading frame to give the entire molecule containing 480 amino acids. The analysis of the sequence shows the presence of four putative Ig-like domains and that some fundamental structural features, like a disulphide bond in domain D2 and the CXC signalling motif in the cytoplasmic tail, are conserved from sea bass to mammals. Real-time PCR analysis showed that very high levels of CD4 mRNA transcripts are present in thymus, followed by gut and gills. In vitro stimulation of head kidney leukocytes with LPS and PHA-L gave an increase of CD4 mRNA levels after 4h and a decrease after 24h. Homology modelling has been applied to create a 3D model of sea bass CD4 and to investigate its interaction with sea bass MHC-II. The analysis of the 3D complex between sea bass CD4 and sea bass MHC-II suggests that the absence of a disulfide bond in the CD4 D1 domain could make this molecule more flexible, inducing a different conformation and affecting the binding and the way of interaction between CD4 and MHC-II. Our results will add new insights into the sea bass T cell immune responses and will help in the identification of T cell subsets in teleost fishes to better understand the evolution of cell-mediated immunity from fish to mammals." @default.
• W2034068913 created "2016-06-24" @default.
• W2034068913 creator A5004127474 @default.
• W2034068913 creator A5026454337 @default.
• W2034068913 creator A5027433240 @default.
• W2034068913 creator A5027523820 @default.
• W2034068913 creator A5032380606 @default.
• W2034068913 creator A5049108063 @default.
• W2034068913 creator A5052813352 @default.
• W2034068913 creator A5055281776 @default.
• W2034068913 creator A5058200937 @default.
• W2034068913 creator A5071269636 @default.
• W2034068913 date "2008-06-01" @default.
• W2034068913 modified "2023-10-16" @default.
• W2034068913 title "A CD4 homologue in sea bass (Dicentrarchus labrax): Molecular characterization and structural analysis" @default.
• W2034068913 cites W1491270159 @default.
• W2034068913 cites W1503419019 @default.
• W2034068913 cites W1595256727 @default.
• W2034068913 cites W1964457244 @default.
• W2034068913 cites W1968385313 @default.
• W2034068913 cites W1969676810 @default.
• W2034068913 cites W1976028300 @default.
• W2034068913 cites W1977302649 @default.
• W2034068913 cites W1982488194 @default.
• W2034068913 cites W1982604885 @default.
• W2034068913 cites W1984266461 @default.
• W2034068913 cites W1985548937 @default.
• W2034068913 cites W1986191025 @default.
• W2034068913 cites W1992354589 @default.
• W2034068913 cites W1993568862 @default.
• W2034068913 cites W2005475669 @default.
• W2034068913 cites W2008708467 @default.
• W2034068913 cites W2009335336 @default.
• W2034068913 cites W2015292449 @default.
• W2034068913 cites W2016064248 @default.
• W2034068913 cites W2018490737 @default.
• W2034068913 cites W2018689712 @default.
• W2034068913 cites W2024441858 @default.
• W2034068913 cites W2026894918 @default.
• W2034068913 cites W2027335510 @default.
• W2034068913 cites W2031772330 @default.
• W2034068913 cites W2036141427 @default.
• W2034068913 cites W2038636618 @default.
• W2034068913 cites W2047163848 @default.
• W2034068913 cites W2051628563 @default.
• W2034068913 cites W2055043387 @default.
• W2034068913 cites W2059912327 @default.
• W2034068913 cites W2060095976 @default.
• W2034068913 cites W2060370489 @default.
• W2034068913 cites W2065283382 @default.
• W2034068913 cites W2065573263 @default.
• W2034068913 cites W2067856401 @default.
• W2034068913 cites W2079355826 @default.
• W2034068913 cites W2079720213 @default.
• W2034068913 cites W2083053234 @default.
• W2034068913 cites W2083393665 @default.
• W2034068913 cites W2086183741 @default.
• W2034068913 cites W2087163507 @default.
• W2034068913 cites W2092136891 @default.
• W2034068913 cites W2106154817 @default.
• W2034068913 cites W2108067237 @default.
• W2034068913 cites W2115560487 @default.
• W2034068913 cites W2127122014 @default.
• W2034068913 cites W2127658176 @default.
• W2034068913 cites W2130408532 @default.
• W2034068913 cites W2132026381 @default.
• W2034068913 cites W2138913459 @default.
• W2034068913 cites W2146396346 @default.
• W2034068913 cites W2155170108 @default.
• W2034068913 cites W2156914590 @default.
• W2034068913 cites W2166720212 @default.
• W2034068913 cites W2167197805 @default.
• W2034068913 cites W2171091522 @default.
• W2034068913 doi "https://doi.org/10.1016/j.molimm.2008.02.024" @default.
• W2034068913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18403019" @default.
• W2034068913 hasPublicationYear "2008" @default.
• W2034068913 type Work @default.
• W2034068913 sameAs 2034068913 @default.
• W2034068913 citedByCount "57" @default.
• W2034068913 countsByYear W20340689132012 @default.
• W2034068913 countsByYear W20340689132013 @default.
• W2034068913 countsByYear W20340689132014 @default.
• W2034068913 countsByYear W20340689132015 @default.
• W2034068913 countsByYear W20340689132016 @default.
• W2034068913 countsByYear W20340689132017 @default.
• W2034068913 countsByYear W20340689132018 @default.
• W2034068913 countsByYear W20340689132019 @default.
• W2034068913 countsByYear W20340689132020 @default.
• W2034068913 countsByYear W20340689132021 @default.
• W2034068913 countsByYear W20340689132022 @default.
• W2034068913 countsByYear W20340689132023 @default.
• W2034068913 crossrefType "journal-article" @default.
• W2034068913 hasAuthorship W2034068913A5004127474 @default.
• W2034068913 hasAuthorship W2034068913A5026454337 @default.
• W2034068913 hasAuthorship W2034068913A5027433240 @default.
• W2034068913 hasAuthorship W2034068913A5027523820 @default.
• W2034068913 hasAuthorship W2034068913A5032380606 @default.
• W2034068913 hasAuthorship W2034068913A5049108063 @default.

• next