FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034089381> ?p ?o ?g. }

• W2034089381 endingPage "139" @default.
• W2034089381 startingPage "135" @default.
• W2034089381 abstract "IL-15 is a pro-inflammatory cytokine whose three-dimensional structure is similar to that of IL-2. IL-2 and IL-15 have similar as well as distinct biological functions. An active form of IL-15 that is membrane bound has also been described. Furthermore, IL-15 is known to play a role in autoimmune diseases. We thus investigated the expression of membrane bound IL-15 on monocytes (CD14+ cells) and studied its effect on T cell activation in MS patients. We found that unstimulated CD14+ cells from relapsing remitting MS patients had increased membrane bound IL-15. Those with high surface levels of IL-15 on monocytes were in the early stages of the disease. In addition, we found that T cells of MS patients had enhanced responsiveness to IL-15 and there was increased expression of IL-15 receptor on CD4+ T cells. Thus, IL-15 may be an important cytokine that drives Th1 responses early in the course of the disease and could serve as a target for immunotherapy and as an early marker in the immunologic staging of MS." @default.
• W2034089381 created "2016-06-24" @default.
• W2034089381 creator A5063619699 @default.
• W2034089381 creator A5069092257 @default.
• W2034089381 creator A5077540596 @default.
• W2034089381 creator A5083966818 @default.
• W2034089381 date "2008-03-01" @default.
• W2034089381 modified "2023-10-16" @default.
• W2034089381 title "Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS" @default.
• W2034089381 cites W1548931116 @default.
• W2034089381 cites W1563727852 @default.
• W2034089381 cites W1567604499 @default.
• W2034089381 cites W1597152265 @default.
• W2034089381 cites W1661041446 @default.
• W2034089381 cites W1739088794 @default.
• W2034089381 cites W1829424702 @default.
• W2034089381 cites W1903544242 @default.
• W2034089381 cites W1968369082 @default.
• W2034089381 cites W1976262436 @default.
• W2034089381 cites W1989292498 @default.
• W2034089381 cites W1998761401 @default.
• W2034089381 cites W1999468258 @default.
• W2034089381 cites W2015360645 @default.
• W2034089381 cites W2017072222 @default.
• W2034089381 cites W2026218766 @default.
• W2034089381 cites W2028345258 @default.
• W2034089381 cites W2051638547 @default.
• W2034089381 cites W2057939648 @default.
• W2034089381 cites W2084105573 @default.
• W2034089381 cites W2093620378 @default.
• W2034089381 cites W2094314727 @default.
• W2034089381 cites W2096764727 @default.
• W2034089381 cites W2102071302 @default.
• W2034089381 cites W2106471879 @default.
• W2034089381 cites W2106980391 @default.
• W2034089381 cites W2113291839 @default.
• W2034089381 cites W2125010485 @default.
• W2034089381 cites W2130983270 @default.
• W2034089381 cites W2139056292 @default.
• W2034089381 cites W2151272317 @default.
• W2034089381 cites W4313343453 @default.
• W2034089381 doi "https://doi.org/10.1016/j.jneuroim.2008.01.016" @default.
• W2034089381 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747383" @default.
• W2034089381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18378324" @default.
• W2034089381 hasPublicationYear "2008" @default.
• W2034089381 type Work @default.
• W2034089381 sameAs 2034089381 @default.
• W2034089381 citedByCount "22" @default.
• W2034089381 countsByYear W20340893812012 @default.
• W2034089381 countsByYear W20340893812013 @default.
• W2034089381 countsByYear W20340893812014 @default.
• W2034089381 countsByYear W20340893812015 @default.
• W2034089381 countsByYear W20340893812016 @default.
• W2034089381 countsByYear W20340893812017 @default.
• W2034089381 countsByYear W20340893812018 @default.
• W2034089381 countsByYear W20340893812019 @default.
• W2034089381 countsByYear W20340893812020 @default.
• W2034089381 countsByYear W20340893812021 @default.
• W2034089381 countsByYear W20340893812023 @default.
• W2034089381 crossrefType "journal-article" @default.
• W2034089381 hasAuthorship W2034089381A5063619699 @default.
• W2034089381 hasAuthorship W2034089381A5069092257 @default.
• W2034089381 hasAuthorship W2034089381A5077540596 @default.
• W2034089381 hasAuthorship W2034089381A5083966818 @default.
• W2034089381 hasBestOaLocation W20340893812 @default.
• W2034089381 hasConcept C126322002 @default.
• W2034089381 hasConcept C170493617 @default.
• W2034089381 hasConcept C185592680 @default.
• W2034089381 hasConcept C191732599 @default.
• W2034089381 hasConcept C203014093 @default.
• W2034089381 hasConcept C2777701055 @default.
• W2034089381 hasConcept C2778513237 @default.
• W2034089381 hasConcept C2778690821 @default.
• W2034089381 hasConcept C2781184567 @default.
• W2034089381 hasConcept C71924100 @default.
• W2034089381 hasConcept C86803240 @default.
• W2034089381 hasConcept C8891405 @default.
• W2034089381 hasConcept C95444343 @default.
• W2034089381 hasConceptScore W2034089381C126322002 @default.
• W2034089381 hasConceptScore W2034089381C170493617 @default.
• W2034089381 hasConceptScore W2034089381C185592680 @default.
• W2034089381 hasConceptScore W2034089381C191732599 @default.
• W2034089381 hasConceptScore W2034089381C203014093 @default.
• W2034089381 hasConceptScore W2034089381C2777701055 @default.
• W2034089381 hasConceptScore W2034089381C2778513237 @default.
• W2034089381 hasConceptScore W2034089381C2778690821 @default.
• W2034089381 hasConceptScore W2034089381C2781184567 @default.
• W2034089381 hasConceptScore W2034089381C71924100 @default.
• W2034089381 hasConceptScore W2034089381C86803240 @default.
• W2034089381 hasConceptScore W2034089381C8891405 @default.
• W2034089381 hasConceptScore W2034089381C95444343 @default.
• W2034089381 hasIssue "1-2" @default.
• W2034089381 hasLocation W20340893811 @default.
• W2034089381 hasLocation W20340893812 @default.
• W2034089381 hasLocation W20340893813 @default.
• W2034089381 hasLocation W20340893814 @default.
• W2034089381 hasOpenAccess W2034089381 @default.
• W2034089381 hasPrimaryLocation W20340893811 @default.

• next