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- W2034090868 abstract "The stereospecific synthesis of nine trans-combretastatin analogs (5 - 13) is described. The trans geometry of these products was ascertained by the vinylenic proton NMR coupling constants of 15 - 16 Hz, and also by a single crystal x-ray structure of the tetramethoxy compound 6. Continuous 3-day exposure of murine B16 melanoma cells to the trans-combretastatin analogs 5 - 13 showed that two of the analogs (2 and 4) had good cytotoxicity. According to a MTT assay, the IC50 values for compounds 2 and 4 were 4.5 μM and 13.5 μM, respectively. Compounds that exhibited cytotoxic properties contain a 4,4-dimethoxy-transstilbene skeleton. Keywords: combretastatin, tubulin, anticancer, chugaev reaction, cytotoxicity" @default.
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- W2034090868 date "2004-07-01" @default.
- W2034090868 modified "2023-09-25" @default.
- W2034090868 title "A Stereospecific Route for the Preparation of Trans-Combretastatin Analogs: Synthesis and Cytotoxicity" @default.
- W2034090868 doi "https://doi.org/10.2174/1570180043398821" @default.
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