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• W2034093039 abstract "The present work analyzes the calmodulin stimulation of rat intestinal epithelial adenylate cyclase. It is shown that: (1) activation of intestinal adenylate cyclase by calmodulin occurs in the presence of 1 – 30 μM free Ca2+; (2) in the 0.5 – 10 mM MgCl2 concentration range, the pattern of calmodulin action is not modified by Mg2+; calmodulin acts by increasing the maximal velocity of the intestinal adenylate cyclase without altering its affinity for ATP and Mg2+; (3) the calmodulin effect does not require the presence of guanine nucleotide and is even additive to that induced by GTP or its synthetic non-hydrolyzable analog guanosine 5′-[β,γ-imido]triphosphate; (4) calmodulin and sodium fluoride exert an additive effect on the enzyme activity; (5) calmodulin and prostaglandins E1 or E2 display additive stimulatory actions, whatever the dose of prostaglandins tested; calmodulin, therefore, does not modify the affinity of intestinal adenylate cyclase for its hormonal effectors; (6) trifluopeazine in the 25–200 μM range of concentrations (K0.5= 85 μM) suppresses the adenylate cyclase activity which has been stimulated by 5 μM calmodulin; (7) calmodulin is active in the 0.1 – 10 μM concentration range, half-maximal stimulation is induced by 0.9 μM protein, i.e. a dose of calmodulin that is much below the calmodulin content of the intestinal epithelial cell; (8) at low (0.5 mM) and high (5 mM) Mg2- concentration, a sixfold and threefold maximal increase of basal activities are observed, respectively. Our data indicate that calmodulin stimulates intestinal adenylate cyclase by a mechanism that is different from the hormonal activation and suggest the presence of a specific regulatory site for calmodulin on the enzyme." @default.
• W2034093039 created "2016-06-24" @default.
• W2034093039 creator A5034429155 @default.
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• W2034093039 date "2005-03-03" @default.
• W2034093039 modified "2023-10-16" @default.
• W2034093039 title "Calmodulin Stimulation of Adenylate Cyclase of Intestinal Epithelium" @default.
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• W2034093039 doi "https://doi.org/10.1111/j.1432-1033.1983.tb07113.x" @default.
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