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• W2034094771 abstract "Inhibition of the lipid phosphatase SH2‐domain containing inositol phosphatase 2 (SHIP2) in L6‐C10 muscle cells, in 3T3‐L1 adipocytes and in the liver of db/db mice has been shown to ameliorate insulin signal transduction and established SHIP2 as a negative regulator of insulin action. Here we show that SHIP2 inhibition in INS1E insulinoma cells increased Akt, glycogen synthase kinase 3 and extracellular signal‐regulated kinases 1 and 2 phosphorylation. SHIP2 inhibition did not prevent palmitate‐induced apoptosis, but increased cell proliferation. Our data raise the interesting possibility that SHIP2 inhibition exerts proliferative effects in β‐cells and further support the attractiveness of a specific inhibition of SHIP2 for the treatment of type 2 diabetes." @default.
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• W2034094771 date "2007-12-03" @default.
• W2034094771 modified "2023-10-17" @default.
• W2034094771 title "Inhibition of SH2-domain containing inositol phosphatase 2 (SHIP2) in insulin producing INS1E cells improves insulin signal transduction and induces proliferation" @default.
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• W2034094771 doi "https://doi.org/10.1016/j.febslet.2007.11.066" @default.
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