FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034095303> ?p ?o ?g. }

• W2034095303 endingPage "1023" @default.
• W2034095303 startingPage "1023" @default.
• W2034095303 abstract "Combination therapy of statin and ezetimibe for the treatment of familial hypercholesterolemia Ian Hamilton-Craig1, Karam Kostner2, David Colquhoun2, Stan Woodhouse21Griffith University School of Medicine, Southport, Queensland, Australia; 2University of Queensland, Brisbane, Queensland, AustraliaAbstract: High-dose potent statin therapy in combination with ezetimibe is now standard practice for the treatment of adult patients with heterozygous familial hypercholesterolemia (heFH), as the result of numerous studies in patients with primary hypercholesterolemia or heFH. These studies have shown the combination to be both effective and safe in the short to medium term. Recently, short-term ezetimibe therapy has also been shown to be effective and safe in combination with statin therapy for children and adolescents with heFH. Effective statin–ezetimibe combination therapy is capable of achieving near-normal lipid profiles in heFH patients, with expected improvement in risk for cardiovascular disease (CVD) and improved life expectancy resulting predominantly from reduction in levels of low-density lipoprotein cholesterol. There are few data to support a pleiotropic action of ezetimibe with regard to CVD benefit, unlike therapy with statins. No serious and unexpected clinical adverse effects of combination statin–ezetimibe therapy have emerged till date, although data are limited in children and adolescents, for whom longer-term studies are required. Recent data suggesting possible proatherogenic effects of ezetimibe require confirmation. One large long-term randomized controlled clinical outcomes trial is in progress in non-FH patients to determine the efficacy and safety of ezetimibe therapy; it is unlikely that such a trial will ever be performed in patients with FH.Keywords: familial hypercholesterolemia, ezetimibe, statin, combination therapy, low-density lipoprotein cholesterol" @default.
• W2034095303 created "2016-06-24" @default.
• W2034095303 creator A5032920007 @default.
• W2034095303 date "2010-11-01" @default.
• W2034095303 modified "2023-10-11" @default.
• W2034095303 title "Combination therapy of statin and ezetimibe for the treatment of familial hypercholesterolemia" @default.
• W2034095303 cites W1458263521 @default.
• W2034095303 cites W156853490 @default.
• W2034095303 cites W1597507340 @default.
• W2034095303 cites W1746224822 @default.
• W2034095303 cites W1964336458 @default.
• W2034095303 cites W1972021378 @default.
• W2034095303 cites W1977032312 @default.
• W2034095303 cites W1986176552 @default.
• W2034095303 cites W1988332050 @default.
• W2034095303 cites W1989492995 @default.
• W2034095303 cites W1990357261 @default.
• W2034095303 cites W1991544641 @default.
• W2034095303 cites W1994424340 @default.
• W2034095303 cites W1995971388 @default.
• W2034095303 cites W2001283681 @default.
• W2034095303 cites W2004195771 @default.
• W2034095303 cites W2007218870 @default.
• W2034095303 cites W2010033213 @default.
• W2034095303 cites W2017496648 @default.
• W2034095303 cites W2017933916 @default.
• W2034095303 cites W2020456860 @default.
• W2034095303 cites W2021807029 @default.
• W2034095303 cites W2021879218 @default.
• W2034095303 cites W2023146232 @default.
• W2034095303 cites W2023857030 @default.
• W2034095303 cites W2023939317 @default.
• W2034095303 cites W2024334311 @default.
• W2034095303 cites W2025787794 @default.
• W2034095303 cites W2027316231 @default.
• W2034095303 cites W2029158612 @default.
• W2034095303 cites W2030060743 @default.
• W2034095303 cites W2032428593 @default.
• W2034095303 cites W2034277425 @default.
• W2034095303 cites W2035530378 @default.
• W2034095303 cites W2037016936 @default.
• W2034095303 cites W2039839472 @default.
• W2034095303 cites W2041112823 @default.
• W2034095303 cites W2047344526 @default.
• W2034095303 cites W2050327095 @default.
• W2034095303 cites W205235323 @default.
• W2034095303 cites W2055043903 @default.
• W2034095303 cites W2058331732 @default.
• W2034095303 cites W2071713779 @default.
• W2034095303 cites W2072549923 @default.
• W2034095303 cites W2072946225 @default.
• W2034095303 cites W2082456099 @default.
• W2034095303 cites W2084242433 @default.
• W2034095303 cites W2091977780 @default.
• W2034095303 cites W2101969945 @default.
• W2034095303 cites W2106343349 @default.
• W2034095303 cites W2108922215 @default.
• W2034095303 cites W2109224891 @default.
• W2034095303 cites W2109528629 @default.
• W2034095303 cites W2111385165 @default.
• W2034095303 cites W2113890084 @default.
• W2034095303 cites W2116416944 @default.
• W2034095303 cites W2118964190 @default.
• W2034095303 cites W2120289695 @default.
• W2034095303 cites W2132725727 @default.
• W2034095303 cites W2136295087 @default.
• W2034095303 cites W2136964217 @default.
• W2034095303 cites W2137983259 @default.
• W2034095303 cites W2144596160 @default.
• W2034095303 cites W2145159095 @default.
• W2034095303 cites W2147346175 @default.
• W2034095303 cites W2150093840 @default.
• W2034095303 cites W2156299572 @default.
• W2034095303 cites W2159224386 @default.
• W2034095303 cites W2167045683 @default.
• W2034095303 cites W2167452227 @default.
• W2034095303 cites W2168876694 @default.
• W2034095303 cites W2187593761 @default.
• W2034095303 cites W2220359027 @default.
• W2034095303 cites W2281107193 @default.
• W2034095303 cites W2324841714 @default.
• W2034095303 cites W2325164377 @default.
• W2034095303 cites W2397501829 @default.
• W2034095303 cites W3144417971 @default.
• W2034095303 cites W3145416957 @default.
• W2034095303 cites W3149985652 @default.
• W2034095303 cites W3152050148 @default.
• W2034095303 cites W3152056175 @default.
• W2034095303 cites W4230870013 @default.
• W2034095303 cites W4247819315 @default.
• W2034095303 doi "https://doi.org/10.2147/vhrm.s13496" @default.
• W2034095303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2988620" @default.
• W2034095303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21127699" @default.
• W2034095303 hasPublicationYear "2010" @default.
• W2034095303 type Work @default.
• W2034095303 sameAs 2034095303 @default.
• W2034095303 citedByCount "35" @default.
• W2034095303 countsByYear W20340953032012 @default.

• next