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- W2034103119 abstract "Anticholinergic drug is often used to treat extrapyramidal symptoms. We measured muscarinic cholinergic receptor (mAchR) occupancy by the oral administration of biperiden in eight healthy subjects using positron emission tomography (PET) and [11C]N-methyl-4-piperidylbenzilate (NMPB). After the baseline scan each subject underwent one or two post-dose PET scans. mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner." @default.
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- W2034103119 date "1999-01-01" @default.
- W2034103119 modified "2023-10-18" @default.
- W2034103119 title "Muscarinic receptor occupancy by biperiden in living human brain" @default.
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- W2034103119 doi "https://doi.org/10.1016/s0024-3205(98)00613-4" @default.
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