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- W2034103215 abstract "The dynamics of P450 and P450 reductase (POR) as they move through lipid bilayers, associate with one another, and how they are partitioned within the membrane are all essential elements of how they function. We have undertaken several super resolution fluorescence imaging and single particle tracking studies (1) to understand the nano-scale heterogeneity of a standard P450 lipid membrane composed of DOPC:DLPC:DLPS (1:1:1 wt), (2) to directly observe how P450 and POR are partitioned within and around the lipid “raft-like” structures that compose the membrane, and (3) how P450 and POR move and interact with one another in this heterogeneous environment. Moreover, we have conducted super resolution reaction mapping studies using resorufin benzyl ether as a substrate to directly observed single molecule metabolism at individual P450 enzymes. These studies have been used to develop a multiphasic discrete state model(s) for protein-protein interactions and give tantalizing insights into the relationships between these interaction and substrate turnover." @default.
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- W2034103215 date "2015-01-01" @default.
- W2034103215 modified "2023-09-29" @default.
- W2034103215 title "Super-Resolution Imaging and Reaction Mapping of P450 3A4 and P450 Reductase in Heterogeneous Biomimetics: Starry Night" @default.
- W2034103215 doi "https://doi.org/10.1016/j.bpj.2014.11.1383" @default.
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