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- W2034103311 abstract "The authors examined the antibody responses of mice orally immunized with pneumococcal polysaccharide (type 23F) or a pneumococcal polysaccharide conjugated to the outer membrane protein complex of Neisseria meningitides (23F-OMPC). These antigens were administered either in solution or entrapped within microcapsules. Only the mice receiving the encapsulated conjugate vaccine produced significant levels of anti-polysaccharide serum antibodies. These responses, observed after a second oral immunization with the conjugate, were predominantly IgG. Thus, the conversion from a T-cell-independent to a T-cell dependent response, achieved through conjugation was maintained following oral delivery. However, no local secretory IgA anti-polysaccharide response was detected in these mice indicating that while the OMPC carrier augments orally induced IgG responses, it was insufficient for the induction of secretory IgA." @default.
- W2034103311 created "2016-06-24" @default.
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- W2034103311 date "1999-01-01" @default.
- W2034103311 modified "2023-09-25" @default.
- W2034103311 title "Oral immunization with a Streptococcal pneumoniae polysaccharide conjugate vaccine in enterocoated microparticles induces serum antibodies against type specific polysaccharides" @default.
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- W2034103311 doi "https://doi.org/10.1016/s0264-410x(98)00118-2" @default.
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