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- W2034103781 endingPage "11" @default.
- W2034103781 startingPage "1" @default.
- W2034103781 abstract "It is generally accepted that the combination of both Plasmodium falciparum parasite and human host factors is involved in the pathogenesis of complicated severe malaria, including cerebral malaria (CM). Among parasite products, the malarial pigment haemozoin (HZ) has been shown to impair the functions of mononuclear and endothelial cells. Different CM models were associated with enhanced levels of matrix metalloproteinases (MMPs), a family of proteolytic enzymes able to disrupt subendothelial basement membrane and tight junctions and shed, activate, or inactivate cytokines, chemokines, and other MMPs through cleavage from their precursors. Among MMPs, a good candidate for targeted therapy might be MMP-9, whose mRNA and protein expression enhancement as well as direct proenzyme activation by HZ have been recently investigated in a series of studies by our group and others. In the present paper the role of HZ and MMP-9 in complicated malaria, as well as their interactions, will be discussed." @default.
- W2034103781 created "2016-06-24" @default.
- W2034103781 creator A5037876895 @default.
- W2034103781 creator A5085160183 @default.
- W2034103781 date "2011-01-01" @default.
- W2034103781 modified "2023-10-11" @default.
- W2034103781 title "Matrix Metalloproteinase-9 and Haemozoin: Wedding Rings for Human Host and<i>Plasmodium falciparum</i>Parasite in Complicated Malaria" @default.
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