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- W2034103821 abstract "The action of γ-rays on the virus-producing and oncogenic capacities of clonal SR-RSV were studied in order to specify the relationships between these two functions. Two kinds of mutants were obtained from viral suspensions heavily irradiated: (1) virions still able to convert cells, but unable to give rise to progeny (sterile oncogenic virions), identified by their ability to produce nonproducing transformed cells; these cells, not activable by superinfection with RAV, were cancerous since they induced graft tumors on the egg CAM. (2) virions unable to transform CO chick embryo cells i.e., having lost the oncogenic capacity, but able to replicate at high titer and to induce a high level of gs antigen. Furthermore, this mutant, called the NT (γ) virus, confers to the cells a high resistance against challenge RSV belonging to the subgroups B and D of avian oncogenic viruses, and a slight resistance against challenge RSV belonging to the subgroup A. The meaning of these facts is discussed. Present results support the previous hypothesis of the independence of oncogenic and virus-producing capacities." @default.
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- W2034103821 date "1970-04-01" @default.
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- W2034103821 title "Radio-induced mutants of the Schmidt-Ruppin strain of Rous sarcoma virus" @default.
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- W2034103821 doi "https://doi.org/10.1016/0042-6822(70)90148-0" @default.
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