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- W2034105791 abstract "We demonstrate bifunctional combined Au-Fe2O3 nanoparticles (NPs) for selectively induction of apoptosis in cancer cells and real-time imaging. The as-prepared Au-Fe2O3 NPs combine the merits of both Au and γ-Fe2O3 NPs, maintaining excellent fluorescence quenching property and catalytic activity. Conjugated with αⅤβ3 integrin-targeting peptide (RGD) and fluorescein isothiocyanate (FITC)-labeled capsase-3 recognition sequence (DEVD) on the Au surface, the resulting RGD/FITC–DEVD–Au-Fe2O3 NPs bind preferentially to integrin αⅤβ3-rich human liver cancer cells (HepG2), sequentially initiate catalytic formation of hydroxyl radicals (OH) and enable the real-time monitoring ofOH-induced caspase-3-dependent apoptosis in these cancer cells. Furthermore, the catalytic activity of RGD/FITC–DEVD–Au-Fe2O3 NPs is much higher than that of individual γ-Fe2O3 NPs due to the polarization effect at the Au-Fe2O3 interface. Such bifunctional Au-Fe2O3 NPs exhibit simultaneous targeting, therapeutic and imaging functions and are therefore promising for future therapeutic applications in cancer." @default.
- W2034105791 created "2016-06-24" @default.
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- W2034105791 date "2012-05-01" @default.
- W2034105791 modified "2023-10-16" @default.
- W2034105791 title "Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging" @default.
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- W2034105791 doi "https://doi.org/10.1016/j.biomaterials.2012.01.047" @default.
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