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- W2034108533 abstract "What causes the positive, negative, and cognitive symptoms of schizophrenia? The importance of circuits is underscored by the finding that no single gene contributes strongly to the disease. Thus, some circuit abnormality to which many proteins can contribute is the likely cause. There are several major hypotheses regarding the circuitry involved: first, a change in the balance of excitation/inhibition in the prefrontal cortex (PFC); second, abnormal EEG oscillations in the gamma range; third, an increase in theta/delta EEG power related to changes in the thalamus (particularly midline nuclei); fourth, hyperactivity in the hippocampus and consequent dopamine hyperfunction; and fifth, deficits in corollary discharge. Evidence for these hypotheses will be reviewed." @default.
- W2034108533 created "2016-06-24" @default.
- W2034108533 creator A5071574342 @default.
- W2034108533 date "2012-06-01" @default.
- W2034108533 modified "2023-10-17" @default.
- W2034108533 title "Excitation, inhibition, local oscillations, or large-scale loops: what causes the symptoms of schizophrenia?" @default.
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- W2034108533 doi "https://doi.org/10.1016/j.conb.2011.10.018" @default.
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