FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034108574> ?p ?o ?g. }

• W2034108574 abstract "Monoamine oxidase (MAO) is an ubiquitous, non-soluble, membrane-bound enzyme, located in the outer membrane of mitochondria. MAO consists of two subtypes, MAO-A and MAO-B, depending on their substrates and sensitivity to inhibitors. MAO consists of two units joined together by a disulphide bond. The two units of MAO and flavin adenine dinucleotide (FAD) form a polymer in the outer membrane of mitochondria. The function of MAO-A is highly dependent on the lipid constituent of mitochondrial membrane, whereas the function of MAO-B does not depend on the lipid status of mitochondrial membrane. Hydrogen peroxide and ammonia are generated during MAO-induced metabolism of its substrates. MAO and its substrates are present in both the exocrine as well as the endocrine parts of the pancreas. In the islet of Langerhans, MAO-A is observed in about 50% of the cells, whereas MAO-B is less abundant and located mainly in the periphery of pancreatic islets. MAO-B is also demonstrated in centroacinar cells and in pancreatic ducts. Electron microscopy studies suggest that MAO is co-localised with insulin in secretory granules of pancreatic beta cells. Pharmacologically, beta-2-adrenoreceptors agonists such as terbutaline can stimulate MAO activity. In contrast, cholinergic muscarinic stimulation does not affect islet MAO activity. MAO activity in pancreatic tissue is significantly reduced in diabetes. This decrease in MAO activity is associated with an increase in pancreatic tissue levels of adrenaline (ADR) and noradrenaline (NA). Studies on the level of 5-hydroxyindoleacetic acid of pancreatic tissues suggest that serotonin level is also increased in diabetics. Many studies show that MAO inhibits insulin secretion. However, some of its substrates including, serotonin, adrenaline and noradrenaline have been shown to stimulate insulin secretion. In conclusion, the activity and subcellular localisation of MAO suggests that MAO may play an important role in pancreatic beta cell function and hence in the pathogenesis of diabetes mellitus." @default.
• W2034108574 created "2016-06-24" @default.
• W2034108574 creator A5071619243 @default.
• W2034108574 creator A5080780590 @default.
• W2034108574 date "2004-01-01" @default.
• W2034108574 modified "2023-09-30" @default.
• W2034108574 title "The Effect of Diabetes Mellitus on the Morphology and Physiology of Monoamine Oxidase in the Pancreas" @default.
• W2034108574 cites W1577728072 @default.
• W2034108574 cites W1912299269 @default.
• W2034108574 cites W1964885781 @default.
• W2034108574 cites W1970075816 @default.
• W2034108574 cites W1972419134 @default.
• W2034108574 cites W1984333103 @default.
• W2034108574 cites W1984971207 @default.
• W2034108574 cites W1994606852 @default.
• W2034108574 cites W1995662370 @default.
• W2034108574 cites W2001829569 @default.
• W2034108574 cites W2015087860 @default.
• W2034108574 cites W2020929702 @default.
• W2034108574 cites W2021584350 @default.
• W2034108574 cites W2029092243 @default.
• W2034108574 cites W2030705688 @default.
• W2034108574 cites W2032467002 @default.
• W2034108574 cites W2033815054 @default.
• W2034108574 cites W2037452822 @default.
• W2034108574 cites W2038067372 @default.
• W2034108574 cites W2038605460 @default.
• W2034108574 cites W2039774541 @default.
• W2034108574 cites W2053006347 @default.
• W2034108574 cites W2067933061 @default.
• W2034108574 cites W2069254822 @default.
• W2034108574 cites W2069626013 @default.
• W2034108574 cites W2070263609 @default.
• W2034108574 cites W2075066593 @default.
• W2034108574 cites W2077484072 @default.
• W2034108574 cites W2081233162 @default.
• W2034108574 cites W2085842844 @default.
• W2034108574 cites W2087852280 @default.
• W2034108574 cites W2090073144 @default.
• W2034108574 cites W2090114150 @default.
• W2034108574 cites W2092112317 @default.
• W2034108574 cites W2095951706 @default.
• W2034108574 cites W2104291189 @default.
• W2034108574 cites W2112550274 @default.
• W2034108574 cites W2124921007 @default.
• W2034108574 cites W2132156136 @default.
• W2034108574 cites W2132520721 @default.
• W2034108574 cites W2170285435 @default.
• W2034108574 cites W2223871648 @default.
• W2034108574 cites W2267963721 @default.
• W2034108574 cites W2273560556 @default.
• W2034108574 cites W2288066764 @default.
• W2034108574 cites W23542705 @default.
• W2034108574 cites W2412470838 @default.
• W2034108574 cites W2418524591 @default.
• W2034108574 cites W2440678021 @default.
• W2034108574 cites W268133979 @default.
• W2034108574 cites W38296339 @default.
• W2034108574 cites W87632982 @default.
• W2034108574 doi "https://doi.org/10.1016/s0161-813x(03)00091-3" @default.
• W2034108574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14697891" @default.
• W2034108574 hasPublicationYear "2004" @default.
• W2034108574 type Work @default.
• W2034108574 sameAs 2034108574 @default.
• W2034108574 citedByCount "19" @default.
• W2034108574 countsByYear W20341085742012 @default.
• W2034108574 countsByYear W20341085742013 @default.
• W2034108574 countsByYear W20341085742014 @default.
• W2034108574 countsByYear W20341085742015 @default.
• W2034108574 countsByYear W20341085742018 @default.
• W2034108574 countsByYear W20341085742021 @default.
• W2034108574 crossrefType "journal-article" @default.
• W2034108574 hasAuthorship W2034108574A5071619243 @default.
• W2034108574 hasAuthorship W2034108574A5080780590 @default.
• W2034108574 hasConcept C103395026 @default.
• W2034108574 hasConcept C126322002 @default.
• W2034108574 hasConcept C134018914 @default.
• W2034108574 hasConcept C165220095 @default.
• W2034108574 hasConcept C181199279 @default.
• W2034108574 hasConcept C185592680 @default.
• W2034108574 hasConcept C2776024655 @default.
• W2034108574 hasConcept C2778764654 @default.
• W2034108574 hasConcept C2779280383 @default.
• W2034108574 hasConcept C2779306644 @default.
• W2034108574 hasConcept C2779855799 @default.
• W2034108574 hasConcept C39398028 @default.
• W2034108574 hasConcept C46699223 @default.
• W2034108574 hasConcept C55493867 @default.
• W2034108574 hasConcept C555293320 @default.
• W2034108574 hasConcept C71315377 @default.
• W2034108574 hasConcept C71924100 @default.
• W2034108574 hasConcept C86803240 @default.
• W2034108574 hasConceptScore W2034108574C103395026 @default.
• W2034108574 hasConceptScore W2034108574C126322002 @default.
• W2034108574 hasConceptScore W2034108574C134018914 @default.
• W2034108574 hasConceptScore W2034108574C165220095 @default.
• W2034108574 hasConceptScore W2034108574C181199279 @default.
• W2034108574 hasConceptScore W2034108574C185592680 @default.
• W2034108574 hasConceptScore W2034108574C2776024655 @default.
• W2034108574 hasConceptScore W2034108574C2778764654 @default.

• next