FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034109146> ?p ?o ?g. }

• W2034109146 endingPage "846" @default.
• W2034109146 startingPage "840" @default.
• W2034109146 abstract "A polymorphism in the serotonin transporter (5-HTT) gene modulates the association between adverse early experiences and risk for major depression in adulthood. Although human imaging studies have begun to elucidate the neural circuits involved in the 5-HTT x environment risk factor, a molecular understanding of this phenomenon is lacking. Such an understanding might help to identify novel targets for the diagnosis and therapy of mood disorders. To address this need, we developed a gene-environment screening paradigm in the mouse.We established a mouse model in which a heterozygous null mutation in 5-HTT moderates the effects of poor maternal care on adult anxiety and depression-related behavior. Biochemical analysis of brains from these animals was performed to identify molecular substrates of the gene, environment, and gene x environment effects.Mice experiencing low maternal care showed deficient gamma-aminobutyric acid-A receptor binding in the amygdala and 5-HTT heterozygous null mice showed decreased serotonin turnover in hippocampus and striatum. Strikingly, levels of brain-derived neurotrophic factor (BDNF) messenger RNA in hippocampus were elevated exclusively in 5-HTT heterozygous null mice experiencing poor maternal care, suggesting that developmental programming of hippocampal circuits might underlie the 5-HTT x environment risk factor.These findings demonstrate that serotonin plays a similar role in modifying the long-term behavioral effects of rearing environment in diverse mammalian species and identifies BDNF as a molecular substrate of this risk factor." @default.
• W2034109146 created "2016-06-24" @default.
• W2034109146 creator A5000640278 @default.
• W2034109146 creator A5020850981 @default.
• W2034109146 creator A5021996413 @default.
• W2034109146 creator A5051277771 @default.
• W2034109146 creator A5052907432 @default.
• W2034109146 creator A5060698725 @default.
• W2034109146 creator A5069738672 @default.
• W2034109146 creator A5078911967 @default.
• W2034109146 date "2008-05-01" @default.
• W2034109146 modified "2023-10-13" @default.
• W2034109146 title "Identifying Molecular Substrates in a Mouse Model of the Serotonin Transporter × Environment Risk Factor for Anxiety and Depression" @default.
• W2034109146 cites W1518574168 @default.
• W2034109146 cites W1602497443 @default.
• W2034109146 cites W1972088939 @default.
• W2034109146 cites W1972861207 @default.
• W2034109146 cites W1973486104 @default.
• W2034109146 cites W1987615735 @default.
• W2034109146 cites W1996814290 @default.
• W2034109146 cites W1997746844 @default.
• W2034109146 cites W2000793737 @default.
• W2034109146 cites W2005415748 @default.
• W2034109146 cites W2005594217 @default.
• W2034109146 cites W2007102622 @default.
• W2034109146 cites W2014001501 @default.
• W2034109146 cites W2037111632 @default.
• W2034109146 cites W2047909845 @default.
• W2034109146 cites W2048294735 @default.
• W2034109146 cites W2049965869 @default.
• W2034109146 cites W2057422453 @default.
• W2034109146 cites W2058210751 @default.
• W2034109146 cites W2059134061 @default.
• W2034109146 cites W2074245141 @default.
• W2034109146 cites W2076894554 @default.
• W2034109146 cites W2086876322 @default.
• W2034109146 cites W2092446347 @default.
• W2034109146 cites W2093316440 @default.
• W2034109146 cites W2093806039 @default.
• W2034109146 cites W2105394148 @default.
• W2034109146 cites W2114462724 @default.
• W2034109146 cites W2117155939 @default.
• W2034109146 cites W2121651624 @default.
• W2034109146 cites W2128480301 @default.
• W2034109146 cites W2130202356 @default.
• W2034109146 cites W2130417276 @default.
• W2034109146 cites W2132167094 @default.
• W2034109146 cites W2143881724 @default.
• W2034109146 cites W2147351252 @default.
• W2034109146 cites W2156303855 @default.
• W2034109146 cites W2156743186 @default.
• W2034109146 cites W2162196924 @default.
• W2034109146 doi "https://doi.org/10.1016/j.biopsych.2007.08.013" @default.
• W2034109146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17949690" @default.
• W2034109146 hasPublicationYear "2008" @default.
• W2034109146 type Work @default.
• W2034109146 sameAs 2034109146 @default.
• W2034109146 citedByCount "125" @default.
• W2034109146 countsByYear W20341091462012 @default.
• W2034109146 countsByYear W20341091462013 @default.
• W2034109146 countsByYear W20341091462014 @default.
• W2034109146 countsByYear W20341091462015 @default.
• W2034109146 countsByYear W20341091462016 @default.
• W2034109146 countsByYear W20341091462017 @default.
• W2034109146 countsByYear W20341091462018 @default.
• W2034109146 countsByYear W20341091462019 @default.
• W2034109146 countsByYear W20341091462020 @default.
• W2034109146 countsByYear W20341091462022 @default.
• W2034109146 countsByYear W20341091462023 @default.
• W2034109146 crossrefType "journal-article" @default.
• W2034109146 hasAuthorship W2034109146A5000640278 @default.
• W2034109146 hasAuthorship W2034109146A5020850981 @default.
• W2034109146 hasAuthorship W2034109146A5021996413 @default.
• W2034109146 hasAuthorship W2034109146A5051277771 @default.
• W2034109146 hasAuthorship W2034109146A5052907432 @default.
• W2034109146 hasAuthorship W2034109146A5060698725 @default.
• W2034109146 hasAuthorship W2034109146A5069738672 @default.
• W2034109146 hasAuthorship W2034109146A5078911967 @default.
• W2034109146 hasConcept C126322002 @default.
• W2034109146 hasConcept C134018914 @default.
• W2034109146 hasConcept C148762608 @default.
• W2034109146 hasConcept C15744967 @default.
• W2034109146 hasConcept C160539049 @default.
• W2034109146 hasConcept C169760540 @default.
• W2034109146 hasConcept C170493617 @default.
• W2034109146 hasConcept C2775864247 @default.
• W2034109146 hasConcept C2778790584 @default.
• W2034109146 hasConcept C2778897192 @default.
• W2034109146 hasConcept C2779144063 @default.
• W2034109146 hasConcept C2781161787 @default.
• W2034109146 hasConcept C5284366 @default.
• W2034109146 hasConcept C71924100 @default.
• W2034109146 hasConcept C86803240 @default.
• W2034109146 hasConceptScore W2034109146C126322002 @default.
• W2034109146 hasConceptScore W2034109146C134018914 @default.
• W2034109146 hasConceptScore W2034109146C148762608 @default.
• W2034109146 hasConceptScore W2034109146C15744967 @default.
• W2034109146 hasConceptScore W2034109146C160539049 @default.

• next