Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034109726> ?p ?o ?g. }
- W2034109726 endingPage "1343" @default.
- W2034109726 startingPage "1331" @default.
- W2034109726 abstract "Freely interacting male rabbits were studied to establish the effect of exogenous testosterone on interferon-γ (IFN-γ) production in peripheral blood mononuclear cells (PBMCs) and to evaluate if this effect is related to season, social rank, plasma corticosterone and glucocorticoid receptors (GcR) in PBMCs. Dominance behavior increases after testosterone propionate (TP) administration only in rank 1 animals, while submission behavior increases after TP only in rank 4 animals, indicating a reinforcing effect of TP on the behavior. Corticosterone and IFN-γ production are higher and GcR binding capacity is lower in spring than in autumn, suggesting that seasonal fluctuations in the immune system may be related to the pattern of secretion of immunomodulatory hormones. In autumn, corticosterone decreases after TP treatment and increases after social interaction, while GcR binding capacity decreases after TP treatment and social interaction. IFN-γ production decreases in spring and increases in autumn after TP treatment plus social interaction, indicating that the modulating action of testosterone is related to the current immune status. The relationship between dominance, testosterone and the immune system in spring is suggested by the finding that GcR binding capacity after TP treatment is directly related to social rank, as confirmed by the positive correlation with dominance behavior frequency. The dominance index is positively correlated with GcR binding capacity and negatively with IFN-γ production before TP treatment, indicating that high receptor activity in immunocompetent cells and low immunoreactivity could be prerequisites for dominance behavior. The immunosuppressive effect of corticosterone and the mechanism of down-regulation on GcR are confirmed by the negative correlations with IFN-γ production and GcR binding capacity." @default.
- W2034109726 created "2016-06-24" @default.
- W2034109726 creator A5001684979 @default.
- W2034109726 creator A5003071058 @default.
- W2034109726 creator A5018465034 @default.
- W2034109726 creator A5067869016 @default.
- W2034109726 creator A5076351048 @default.
- W2034109726 creator A5085291201 @default.
- W2034109726 date "2003-02-01" @default.
- W2034109726 modified "2023-09-26" @default.
- W2034109726 title "IFN-γ production in rabbits: Behavioral and endocrine correlates" @default.
- W2034109726 cites W1215373674 @default.
- W2034109726 cites W1519063308 @default.
- W2034109726 cites W1569234041 @default.
- W2034109726 cites W1963723844 @default.
- W2034109726 cites W1964008575 @default.
- W2034109726 cites W1964599123 @default.
- W2034109726 cites W1970382747 @default.
- W2034109726 cites W1970930879 @default.
- W2034109726 cites W1976998675 @default.
- W2034109726 cites W1977143695 @default.
- W2034109726 cites W1982093100 @default.
- W2034109726 cites W1983649348 @default.
- W2034109726 cites W1985941348 @default.
- W2034109726 cites W1987011968 @default.
- W2034109726 cites W1987954441 @default.
- W2034109726 cites W1994367842 @default.
- W2034109726 cites W2002101305 @default.
- W2034109726 cites W2006955905 @default.
- W2034109726 cites W2017098602 @default.
- W2034109726 cites W2017834374 @default.
- W2034109726 cites W2027590367 @default.
- W2034109726 cites W2027788137 @default.
- W2034109726 cites W2030219574 @default.
- W2034109726 cites W2034534545 @default.
- W2034109726 cites W2036900908 @default.
- W2034109726 cites W2040362798 @default.
- W2034109726 cites W2054865288 @default.
- W2034109726 cites W2055516348 @default.
- W2034109726 cites W2059386374 @default.
- W2034109726 cites W2059846999 @default.
- W2034109726 cites W2063775400 @default.
- W2034109726 cites W2073022174 @default.
- W2034109726 cites W2077735554 @default.
- W2034109726 cites W2078121933 @default.
- W2034109726 cites W2080947349 @default.
- W2034109726 cites W2082405085 @default.
- W2034109726 cites W2092060676 @default.
- W2034109726 cites W2105360761 @default.
- W2034109726 cites W2109531160 @default.
- W2034109726 cites W2112386284 @default.
- W2034109726 cites W2119573232 @default.
- W2034109726 cites W2128838531 @default.
- W2034109726 cites W2148992376 @default.
- W2034109726 cites W2150641377 @default.
- W2034109726 cites W2161277545 @default.
- W2034109726 cites W4252271767 @default.
- W2034109726 doi "https://doi.org/10.1016/s0024-3205(02)02378-0" @default.
- W2034109726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12527031" @default.
- W2034109726 hasPublicationYear "2003" @default.
- W2034109726 type Work @default.
- W2034109726 sameAs 2034109726 @default.
- W2034109726 citedByCount "5" @default.
- W2034109726 countsByYear W20341097262013 @default.
- W2034109726 countsByYear W20341097262020 @default.
- W2034109726 crossrefType "journal-article" @default.
- W2034109726 hasAuthorship W2034109726A5001684979 @default.
- W2034109726 hasAuthorship W2034109726A5003071058 @default.
- W2034109726 hasAuthorship W2034109726A5018465034 @default.
- W2034109726 hasAuthorship W2034109726A5067869016 @default.
- W2034109726 hasAuthorship W2034109726A5076351048 @default.
- W2034109726 hasAuthorship W2034109726A5085291201 @default.
- W2034109726 hasConcept C104317684 @default.
- W2034109726 hasConcept C126322002 @default.
- W2034109726 hasConcept C134018914 @default.
- W2034109726 hasConcept C137061746 @default.
- W2034109726 hasConcept C151913843 @default.
- W2034109726 hasConcept C170493617 @default.
- W2034109726 hasConcept C202751555 @default.
- W2034109726 hasConcept C203014093 @default.
- W2034109726 hasConcept C2776178377 @default.
- W2034109726 hasConcept C2779279991 @default.
- W2034109726 hasConcept C2780352252 @default.
- W2034109726 hasConcept C2780841215 @default.
- W2034109726 hasConcept C46699223 @default.
- W2034109726 hasConcept C55493867 @default.
- W2034109726 hasConcept C59493245 @default.
- W2034109726 hasConcept C71315377 @default.
- W2034109726 hasConcept C71924100 @default.
- W2034109726 hasConcept C86803240 @default.
- W2034109726 hasConcept C8891405 @default.
- W2034109726 hasConceptScore W2034109726C104317684 @default.
- W2034109726 hasConceptScore W2034109726C126322002 @default.
- W2034109726 hasConceptScore W2034109726C134018914 @default.
- W2034109726 hasConceptScore W2034109726C137061746 @default.
- W2034109726 hasConceptScore W2034109726C151913843 @default.
- W2034109726 hasConceptScore W2034109726C170493617 @default.
- W2034109726 hasConceptScore W2034109726C202751555 @default.