FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034109874> ?p ?o ?g. }

• W2034109874 endingPage "88" @default.
• W2034109874 startingPage "83" @default.
• W2034109874 abstract "Detailed studies were undertaken to better define the role of the liver and the folate enterohepatic cycle in folate homeostasis. Three isotopes of folate were employed in a rat model to study several parameters: (a) intestinal transport; (b) variation in hepatic uptake after different routes of administration; (c) hepatic reduction, methylation, and polyglutamate formation; (d) biliary excretion; (e) transport of folate to tissue and its return to liver for re-entry into the enterohepatic cycle. Folate absorption was not affected by the type of folate administered, but subsequent liver accumulation was greater when PteGlu(1) was given rather than CH(3)H(4)PteGlu(1). After liver uptake, CH(3)H(4)PteGlu(1) is rapidly and quantitatively excreted into bile, whereas nonmethylated folates are either methylated and transported into bile or incorporated into a hepatic polyglutamate pool. Bile folate is then reabsorbed for distribution to both tissue and liver, completing the enterohepatic cycle. The importance of this cycle was demonstrated by long-term bile drainage and by transport studies with two isotopes of CH(3)H(4)PteGlu(1). With bile drainage, serum folate levels fell to 30-40% of normal within 6 h, a much more dramatic drop than that seen with folate-free diets alone. Studies with labeled CH(3)H(4)PteGlu(1) demonstrated that about one-third was taken up by tissue, demethylated, and returned to liver for remethylation and recirculation through the bile and gut. This establishes the enterohepatic cycle as a major factor in folate homeostasis and, for the first time, demonstrates a transport pathway between tissue and liver for nonmethylated folate." @default.
• W2034109874 created "2016-06-24" @default.
• W2034109874 creator A5039438354 @default.
• W2034109874 creator A5053046630 @default.
• W2034109874 creator A5081092604 @default.
• W2034109874 date "1979-07-01" @default.
• W2034109874 modified "2023-10-16" @default.
• W2034109874 title "Kinetics of the Normal Folate Enterohepatic Cycle" @default.
• W2034109874 cites W129457877 @default.
• W2034109874 cites W1944805172 @default.
• W2034109874 cites W1984756386 @default.
• W2034109874 cites W1996034180 @default.
• W2034109874 cites W2002663495 @default.
• W2034109874 cites W2007072103 @default.
• W2034109874 cites W2015309444 @default.
• W2034109874 cites W2022235718 @default.
• W2034109874 cites W2023615280 @default.
• W2034109874 cites W2059940427 @default.
• W2034109874 cites W2066584427 @default.
• W2034109874 cites W2078393504 @default.
• W2034109874 cites W2079749663 @default.
• W2034109874 cites W2094772473 @default.
• W2034109874 cites W2099047866 @default.
• W2034109874 cites W2136433513 @default.
• W2034109874 cites W2138787070 @default.
• W2034109874 cites W2291572359 @default.
• W2034109874 cites W2296763209 @default.
• W2034109874 cites W2309183107 @default.
• W2034109874 cites W2310515168 @default.
• W2034109874 cites W2316257490 @default.
• W2034109874 cites W2318510381 @default.
• W2034109874 cites W2326381577 @default.
• W2034109874 cites W2388165347 @default.
• W2034109874 cites W2411937218 @default.
• W2034109874 cites W2431844958 @default.
• W2034109874 cites W3119180127 @default.
• W2034109874 cites W38240868 @default.
• W2034109874 doi "https://doi.org/10.1172/jci109467" @default.
• W2034109874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/372093" @default.
• W2034109874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/447863" @default.
• W2034109874 hasPublicationYear "1979" @default.
• W2034109874 type Work @default.
• W2034109874 sameAs 2034109874 @default.
• W2034109874 citedByCount "118" @default.
• W2034109874 countsByYear W20341098742012 @default.
• W2034109874 countsByYear W20341098742013 @default.
• W2034109874 countsByYear W20341098742015 @default.
• W2034109874 countsByYear W20341098742016 @default.
• W2034109874 countsByYear W20341098742017 @default.
• W2034109874 countsByYear W20341098742018 @default.
• W2034109874 countsByYear W20341098742019 @default.
• W2034109874 countsByYear W20341098742020 @default.
• W2034109874 countsByYear W20341098742021 @default.
• W2034109874 countsByYear W20341098742022 @default.
• W2034109874 countsByYear W20341098742023 @default.
• W2034109874 crossrefType "journal-article" @default.
• W2034109874 hasAuthorship W2034109874A5039438354 @default.
• W2034109874 hasAuthorship W2034109874A5053046630 @default.
• W2034109874 hasAuthorship W2034109874A5081092604 @default.
• W2034109874 hasBestOaLocation W20341098741 @default.
• W2034109874 hasConcept C10146269 @default.
• W2034109874 hasConcept C126322002 @default.
• W2034109874 hasConcept C134018914 @default.
• W2034109874 hasConcept C185592680 @default.
• W2034109874 hasConcept C2778620825 @default.
• W2034109874 hasConcept C55493867 @default.
• W2034109874 hasConcept C62231903 @default.
• W2034109874 hasConcept C71924100 @default.
• W2034109874 hasConcept C86803240 @default.
• W2034109874 hasConceptScore W2034109874C10146269 @default.
• W2034109874 hasConceptScore W2034109874C126322002 @default.
• W2034109874 hasConceptScore W2034109874C134018914 @default.
• W2034109874 hasConceptScore W2034109874C185592680 @default.
• W2034109874 hasConceptScore W2034109874C2778620825 @default.
• W2034109874 hasConceptScore W2034109874C55493867 @default.
• W2034109874 hasConceptScore W2034109874C62231903 @default.
• W2034109874 hasConceptScore W2034109874C71924100 @default.
• W2034109874 hasConceptScore W2034109874C86803240 @default.
• W2034109874 hasIssue "1" @default.
• W2034109874 hasLocation W20341098741 @default.
• W2034109874 hasLocation W20341098742 @default.
• W2034109874 hasLocation W20341098743 @default.
• W2034109874 hasLocation W20341098744 @default.
• W2034109874 hasOpenAccess W2034109874 @default.
• W2034109874 hasPrimaryLocation W20341098741 @default.
• W2034109874 hasRelatedWork W1978634877 @default.
• W2034109874 hasRelatedWork W1999077459 @default.
• W2034109874 hasRelatedWork W2008927375 @default.
• W2034109874 hasRelatedWork W2021846613 @default.
• W2034109874 hasRelatedWork W2028993205 @default.
• W2034109874 hasRelatedWork W2041949500 @default.
• W2034109874 hasRelatedWork W2121388961 @default.
• W2034109874 hasRelatedWork W2154101925 @default.
• W2034109874 hasRelatedWork W2748952813 @default.
• W2034109874 hasRelatedWork W4240148004 @default.
• W2034109874 hasVolume "64" @default.
• W2034109874 isParatext "false" @default.
• W2034109874 isRetracted "false" @default.

• next