FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034111802> ?p ?o ?g. }

• W2034111802 endingPage "15511" @default.
• W2034111802 startingPage "15504" @default.
• W2034111802 abstract "In the identification of a metal-binding site within enzymes, kinetic analyses based on thio-effects and Cd2+-rescues are widely used. In those analyses, kinetic studies using a phosphorothioate have been discussed on the premise that the substitution by a sulfur atom does not change the conformation of a ribozyme. However, our present NMR structural analysis demonstrates the change of the conformation at the metal-binding site by Rp-sulfur but not by Sp-sulfur substitution and warns against incautious interpretations of thio-effects and rescue phenomena in kinetic studies using a phosphorothioate. Our analysis further demonstrates that, in solution, a Cd2+ ion can interact with an Rp-phosphorothioate (in support of the controversial McKay's structure, Nature 1994, 372, 68−74) and with an Sp-phosphorothioate (in support of the controversial Scott's structure, Cell 1995, 81, 991−1002) at the metal-binding A9/G10.1 site and that, in the former case, the bound Cd2+ ion can return the ribozyme to an active conformation and rescue its enzymatic activity." @default.
• W2034111802 created "2016-06-24" @default.
• W2034111802 creator A5034223605 @default.
• W2034111802 creator A5048761862 @default.
• W2034111802 creator A5062991341 @default.
• W2034111802 creator A5091898873 @default.
• W2034111802 date "2004-11-09" @default.
• W2034111802 modified "2023-09-25" @default.
• W2034111802 title "NMR-Based Reappraisal of the Coordination of a Metal Ion at the Pro-<i>R</i>p Oxygen of the A9/G10.1 Site in a Hammerhead Ribozyme" @default.
• W2034111802 cites W1975496808 @default.
• W2034111802 cites W1979211342 @default.
• W2034111802 cites W1980254677 @default.
• W2034111802 cites W1984644284 @default.
• W2034111802 cites W1985956065 @default.
• W2034111802 cites W1996746539 @default.
• W2034111802 cites W1996969492 @default.
• W2034111802 cites W2002048308 @default.
• W2034111802 cites W2011369301 @default.
• W2034111802 cites W2011429194 @default.
• W2034111802 cites W2024306464 @default.
• W2034111802 cites W2036060206 @default.
• W2034111802 cites W2039326418 @default.
• W2034111802 cites W2052349384 @default.
• W2034111802 cites W2052935957 @default.
• W2034111802 cites W2069887119 @default.
• W2034111802 cites W2070895458 @default.
• W2034111802 cites W2074774441 @default.
• W2034111802 cites W2088833987 @default.
• W2034111802 cites W2090062467 @default.
• W2034111802 cites W2100598468 @default.
• W2034111802 cites W2104203345 @default.
• W2034111802 cites W2109115256 @default.
• W2034111802 cites W2109677411 @default.
• W2034111802 cites W2141601045 @default.
• W2034111802 cites W2149199200 @default.
• W2034111802 cites W2149943912 @default.
• W2034111802 cites W2150617343 @default.
• W2034111802 cites W2165143835 @default.
• W2034111802 cites W2313618520 @default.
• W2034111802 cites W4236945582 @default.
• W2034111802 doi "https://doi.org/10.1021/ja0472937" @default.
• W2034111802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15563179" @default.
• W2034111802 hasPublicationYear "2004" @default.
• W2034111802 type Work @default.
• W2034111802 sameAs 2034111802 @default.
• W2034111802 citedByCount "27" @default.
• W2034111802 countsByYear W20341118022012 @default.
• W2034111802 countsByYear W20341118022013 @default.
• W2034111802 countsByYear W20341118022014 @default.
• W2034111802 countsByYear W20341118022017 @default.
• W2034111802 countsByYear W20341118022018 @default.
• W2034111802 countsByYear W20341118022021 @default.
• W2034111802 crossrefType "journal-article" @default.
• W2034111802 hasAuthorship W2034111802A5034223605 @default.
• W2034111802 hasAuthorship W2034111802A5048761862 @default.
• W2034111802 hasAuthorship W2034111802A5062991341 @default.
• W2034111802 hasAuthorship W2034111802A5091898873 @default.
• W2034111802 hasConcept C104317684 @default.
• W2034111802 hasConcept C107745601 @default.
• W2034111802 hasConcept C107824862 @default.
• W2034111802 hasConcept C178790620 @default.
• W2034111802 hasConcept C181199279 @default.
• W2034111802 hasConcept C185592680 @default.
• W2034111802 hasConcept C2779792011 @default.
• W2034111802 hasConcept C2781253882 @default.
• W2034111802 hasConcept C41183919 @default.
• W2034111802 hasConcept C518881349 @default.
• W2034111802 hasConcept C544153396 @default.
• W2034111802 hasConcept C55493867 @default.
• W2034111802 hasConcept C67705224 @default.
• W2034111802 hasConcept C71240020 @default.
• W2034111802 hasConcept C76346623 @default.
• W2034111802 hasConcept C8010536 @default.
• W2034111802 hasConceptScore W2034111802C104317684 @default.
• W2034111802 hasConceptScore W2034111802C107745601 @default.
• W2034111802 hasConceptScore W2034111802C107824862 @default.
• W2034111802 hasConceptScore W2034111802C178790620 @default.
• W2034111802 hasConceptScore W2034111802C181199279 @default.
• W2034111802 hasConceptScore W2034111802C185592680 @default.
• W2034111802 hasConceptScore W2034111802C2779792011 @default.
• W2034111802 hasConceptScore W2034111802C2781253882 @default.
• W2034111802 hasConceptScore W2034111802C41183919 @default.
• W2034111802 hasConceptScore W2034111802C518881349 @default.
• W2034111802 hasConceptScore W2034111802C544153396 @default.
• W2034111802 hasConceptScore W2034111802C55493867 @default.
• W2034111802 hasConceptScore W2034111802C67705224 @default.
• W2034111802 hasConceptScore W2034111802C71240020 @default.
• W2034111802 hasConceptScore W2034111802C76346623 @default.
• W2034111802 hasConceptScore W2034111802C8010536 @default.
• W2034111802 hasIssue "47" @default.
• W2034111802 hasLocation W20341118021 @default.
• W2034111802 hasLocation W20341118022 @default.
• W2034111802 hasOpenAccess W2034111802 @default.
• W2034111802 hasPrimaryLocation W20341118021 @default.
• W2034111802 hasRelatedWork W1975820674 @default.
• W2034111802 hasRelatedWork W1983955493 @default.
• W2034111802 hasRelatedWork W2015248075 @default.
• W2034111802 hasRelatedWork W2122934240 @default.

• next