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- W2034111955 abstract "ABSTRACT High-level expression of the major pilus subunit (PapA) of uropathogenic strains of Escherichia coli results in part from the unusually long lifetime of the mRNA that encodes this protein. Here we report that the longevity of papA mRNA derives in large measure from the protection afforded by its 5′ untranslated region. This papA RNA segment can prolong the lifetime of an otherwise short-lived mRNA to which it is fused. In vivo alkylation studies indicate that, in its natural milieu, the papA message begins with a stem-loop structure. This stem-loop is important for the stabilizing effect of the papA 5′ untranslated region, as evidenced by the significant acceleration in papA mRNA decay that results from its removal." @default.
- W2034111955 created "2016-06-24" @default.
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- W2034111955 date "1999-06-01" @default.
- W2034111955 modified "2023-10-15" @default.
- W2034111955 title "Importance of a 5′ Stem-Loop for Longevity of <i>papA</i> mRNA in <i>Escherichia coli</i>" @default.
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- W2034111955 doi "https://doi.org/10.1128/jb.181.11.3587-3590.1999" @default.
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