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- W2034112368 abstract "To compare endogenous serum growth hormone concentrations over a 24-hour period in patients with chronic heart failure (CHF) and matched controls.Prospective, 24-hour, endogenous concentration comparison.Hospital research center.Eight evaluable patients with nonischemic dilated cardiomyopathy and 10 healthy control subjects, matched for age and sex.Over a 24-hour period, blood was drawn from the study participants every 20 minutes for determination of growth hormone.For each patient, the area under the concentration-time curve from time 0-24 hours (AUC0-24), maximum concentration (Cmax), and minimum concentration (Cnadir) of growth hormone were determined. The AUC0-24 and Cmax were 74% (p < 0.05) and 62% (p < 0.05) lower in patients with CHF than in controls, respectively. The Cnadir for all participants was 0 microg/L. Variability in growth hormone concentrations over the 24 hours was considerable for all study participants.Growth hormone concentrations are suppressed over a 24-hour period in patients with CHF versus healthy controls. Variability in levels throughout the day suggests that a single point evaluation cannot be used to determine deficiency or abundance of growth hormone." @default.
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- W2034112368 date "2003-02-01" @default.
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- W2034112368 title "A 24-Hour Comparison of Serum Growth Hormone Concentrations in Patients with Heart Failure versus Healthy Controls" @default.
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- W2034112368 doi "https://doi.org/10.1592/phco.23.2.147.32093" @default.
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