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• W2034113480 endingPage "4938" @default.
• W2034113480 startingPage "4919" @default.
• W2034113480 abstract "Adenovirus DNA replication is inhibited by aphidicolin but the inhibition clearly has different parameters than the inhibition of purified DNA polymerase α. In adenovirus infected Hela cells, 10 μg/ml of aphidicolin reduced viral DNA synthesis by 80%. Cellular DNA synthesis was inhibited by 97% at 0.1 μg/ml. 10 μg/ml of drug had no effect on virus yield or late protein synthesis though higher concentrations of drug (50 ug/ml) caused an abrupt cessation of late protein synthesis and 100 μg/ml reduced virus yield by 3 logs. Concentrations of the drug from 0.5 μg/ml to 10 μg/ml were found to dramatically slow the rate of DNA chain elongation in vitro but not stop it completely, so that over a long period of time net incorporation was reduced only slightly compared to the control. 50 μg/ml or 100 μg/ml of drug completely inhibited incorporation in vitro . Initiation of viral DNA repTTcafion - covalent attachment of dCMP to the preterminal protein - occurs in vitro . This reaction was found to be insensitive to inhibition by aphidicblin. We thus conclude that aphidicolin exerts its effect on adenovirus DNA chain elongation, but not on the primary initiation event of protein priming." @default.
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• W2034113480 date "1981-01-01" @default.
• W2034113480 modified "2023-09-30" @default.
• W2034113480 title "Characterization of the effect of aphidicolin on adenovirus DNA replication: evidence in support of a protein primer model of initiation" @default.
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• W2034113480 doi "https://doi.org/10.1093/nar/9.19.4919" @default.
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