FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034116082> ?p ?o ?g. }

• W2034116082 endingPage "e649" @default.
• W2034116082 startingPage "e649" @default.
• W2034116082 abstract "CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays.Here we used a novel HLA-DR1 tetramer containing a highly targeted CD4+ T cell epitope from the hepatitis C virus non-structural protein 4 to track number and phenotype of hepatitis C virus specific CD4+ T cells in a cohort of seven HLA-DR1 positive patients with acute hepatitis C in comparison to patients with chronic or resolved hepatitis C. We observed peptide-specific T cells in all seven patients with acute hepatitis C regardless of outcome at frequencies up to 0.65% of CD4+ T cells. Among patients who transiently controlled virus replication we observed loss of function, and/or physical deletion of tetramer+ CD4+ T cells before viral recrudescence. In some patients with chronic hepatitis C very low numbers of tetramer+ cells were detectable in peripheral blood, compared to robust responses detected in spontaneous resolvers. Importantly we did not observe escape mutations in this key CD4+ T cell epitope in patients with evolving chronic hepatitis C.During acute hepatitis C a CD4+ T cell response against this epitope is readily induced in most, if not all, HLA-DR1+ patients. This antiviral T cell population becomes functionally impaired or is deleted early in the course of disease in those where viremia persists." @default.
• W2034116082 created "2016-06-24" @default.
• W2034116082 creator A5001255253 @default.
• W2034116082 creator A5004014900 @default.
• W2034116082 creator A5007241760 @default.
• W2034116082 creator A5011530744 @default.
• W2034116082 creator A5013323616 @default.
• W2034116082 creator A5014615779 @default.
• W2034116082 creator A5029546143 @default.
• W2034116082 creator A5031165744 @default.
• W2034116082 creator A5038953045 @default.
• W2034116082 creator A5043829341 @default.
• W2034116082 creator A5044524026 @default.
• W2034116082 creator A5051477244 @default.
• W2034116082 creator A5051791661 @default.
• W2034116082 creator A5052030378 @default.
• W2034116082 creator A5054826514 @default.
• W2034116082 creator A5055107421 @default.
• W2034116082 creator A5067056877 @default.
• W2034116082 creator A5070805632 @default.
• W2034116082 creator A5071202895 @default.
• W2034116082 creator A5075459069 @default.
• W2034116082 creator A5077574568 @default.
• W2034116082 creator A5080161419 @default.
• W2034116082 creator A5083649209 @default.
• W2034116082 creator A5085265275 @default.
• W2034116082 creator A5088630101 @default.
• W2034116082 creator A5091414511 @default.
• W2034116082 date "2007-07-25" @default.
• W2034116082 modified "2023-10-18" @default.
• W2034116082 title "Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection" @default.
• W2034116082 cites W1521591765 @default.
• W2034116082 cites W1920703804 @default.
• W2034116082 cites W1972573940 @default.
• W2034116082 cites W1980215946 @default.
• W2034116082 cites W1981136135 @default.
• W2034116082 cites W1990058709 @default.
• W2034116082 cites W2013740977 @default.
• W2034116082 cites W2028108781 @default.
• W2034116082 cites W2028151227 @default.
• W2034116082 cites W2037161720 @default.
• W2034116082 cites W2042167668 @default.
• W2034116082 cites W2044757144 @default.
• W2034116082 cites W2084446925 @default.
• W2034116082 cites W2101832306 @default.
• W2034116082 cites W2103802132 @default.
• W2034116082 cites W2107749930 @default.
• W2034116082 cites W2111359040 @default.
• W2034116082 cites W2112445289 @default.
• W2034116082 cites W2113575403 @default.
• W2034116082 cites W2118603976 @default.
• W2034116082 cites W2123947458 @default.
• W2034116082 cites W2130259551 @default.
• W2034116082 cites W2141650341 @default.
• W2034116082 cites W2170946314 @default.
• W2034116082 cites W4245799938 @default.
• W2034116082 cites W4246786761 @default.
• W2034116082 doi "https://doi.org/10.1371/journal.pone.0000649" @default.
• W2034116082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1920556" @default.
• W2034116082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17653276" @default.
• W2034116082 hasPublicationYear "2007" @default.
• W2034116082 type Work @default.
• W2034116082 sameAs 2034116082 @default.
• W2034116082 citedByCount "68" @default.
• W2034116082 countsByYear W20341160822012 @default.
• W2034116082 countsByYear W20341160822013 @default.
• W2034116082 countsByYear W20341160822014 @default.
• W2034116082 countsByYear W20341160822015 @default.
• W2034116082 countsByYear W20341160822016 @default.
• W2034116082 countsByYear W20341160822017 @default.
• W2034116082 countsByYear W20341160822018 @default.
• W2034116082 countsByYear W20341160822020 @default.
• W2034116082 countsByYear W20341160822023 @default.
• W2034116082 crossrefType "journal-article" @default.
• W2034116082 hasAuthorship W2034116082A5001255253 @default.
• W2034116082 hasAuthorship W2034116082A5004014900 @default.
• W2034116082 hasAuthorship W2034116082A5007241760 @default.
• W2034116082 hasAuthorship W2034116082A5011530744 @default.
• W2034116082 hasAuthorship W2034116082A5013323616 @default.
• W2034116082 hasAuthorship W2034116082A5014615779 @default.
• W2034116082 hasAuthorship W2034116082A5029546143 @default.
• W2034116082 hasAuthorship W2034116082A5031165744 @default.
• W2034116082 hasAuthorship W2034116082A5038953045 @default.
• W2034116082 hasAuthorship W2034116082A5043829341 @default.
• W2034116082 hasAuthorship W2034116082A5044524026 @default.
• W2034116082 hasAuthorship W2034116082A5051477244 @default.
• W2034116082 hasAuthorship W2034116082A5051791661 @default.
• W2034116082 hasAuthorship W2034116082A5052030378 @default.
• W2034116082 hasAuthorship W2034116082A5054826514 @default.
• W2034116082 hasAuthorship W2034116082A5055107421 @default.
• W2034116082 hasAuthorship W2034116082A5067056877 @default.
• W2034116082 hasAuthorship W2034116082A5070805632 @default.
• W2034116082 hasAuthorship W2034116082A5071202895 @default.
• W2034116082 hasAuthorship W2034116082A5075459069 @default.
• W2034116082 hasAuthorship W2034116082A5077574568 @default.
• W2034116082 hasAuthorship W2034116082A5080161419 @default.
• W2034116082 hasAuthorship W2034116082A5083649209 @default.
• W2034116082 hasAuthorship W2034116082A5085265275 @default.

• next