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- W2034118045 abstract "DNA replication is an extremely accurate process and cells have evolved intricate control mechanisms to ensure that each region of their genome is replicated only once during S phase. Here, we compare what is known about the processes that prevent re-replication in prokaryotic and eukaryotic cells by using the model organisms Escherichia coli and Schizosaccharomyces pombe as examples. Although the underlying molecular details are different, the logic behind the control mechanisms is similar. For example, after initiation, crucial molecules required for the loading of replicative helicases in both prokaryotes and eukaryotes are inactivated until the next cell cycle. Furthermore, in both systems the beta-clamp of the replicative polymerase associates with enzymatic activities that contribute to the inactivation of the helicase loaders. Finally, recent studies suggest that the control mechanism that prevents re-replication in both systems also increases the synthesis of DNA building blocks." @default.
- W2034118045 created "2016-06-24" @default.
- W2034118045 creator A5018373535 @default.
- W2034118045 creator A5090943872 @default.
- W2034118045 date "2008-02-01" @default.
- W2034118045 modified "2023-10-18" @default.
- W2034118045 title "Once in a lifetime: strategies for preventing re‐replication in prokaryotic and eukaryotic cells" @default.
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- W2034118045 doi "https://doi.org/10.1038/sj.embor.2008.2" @default.
- W2034118045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2246403" @default.
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