Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034120777> ?p ?o ?g. }
- W2034120777 endingPage "409" @default.
- W2034120777 startingPage "399" @default.
- W2034120777 abstract "Cantharis vesicatoria (blister beetle) is used in Chinese medicine and has been categorized as highly toxic in the Chinese pharmacopeia. In Europe, Cantharis patches have been used since ages to treat various skin-related diseases. We investigated the cytotoxicity of the Cantharis ingredient, cantharidin, in 41 tumor cell lines (Oncotest panel) and compared the results with those of 60 cell lines of the National Cancer Institute, USA. We found profound activity at low micromolar concentrations (log10IC50 values between −6.980 and 5.009 M). Cantharidin bound to protein phosphatase 2A (PP2A) with higher affinity (−8.12 kcal/mol) than to PP1 (−6.25 kcal/mol) in molecular docking analyses. Using a PCR array for 84 apoptosis genes, cantharidin treatment upregulated gene expression of caspase-1 and nerve growth factor receptor, but downregulated mRNA expression of Bcl-2 like protein 10, Fas ligand, and tumor necrosis factor-α. By using COMPARE analysis of microarray-based transcriptome-wide mRNA expressions, 21 genes were found to significantly correlate with response of 60 tumor cell lines to cantharidin. As shown by hierarchical cluster analysis and chi-squared test, the distribution of cell lines in the dendrogram according to their gene expression profiles predicted sensitivity or resistance to cantharidin (P = 6.482 × 10−5). The compassionate use of Cantharis patches in two patients suffering from basalioma and Mycosis fungoides, respectively, considerably improved the diseases without signs of toxicity. In conclusion, these results indicate that cantharidin may be a useful candidate to develop novel strategies for cancer therapy." @default.
- W2034120777 created "2016-06-24" @default.
- W2034120777 creator A5006197653 @default.
- W2034120777 creator A5052981792 @default.
- W2034120777 creator A5062304427 @default.
- W2034120777 creator A5062826138 @default.
- W2034120777 creator A5071993355 @default.
- W2034120777 creator A5086545510 @default.
- W2034120777 creator A5087702568 @default.
- W2034120777 date "2014-02-01" @default.
- W2034120777 modified "2023-10-15" @default.
- W2034120777 title "Pharmacogenomics of cantharidin in tumor cells" @default.
- W2034120777 cites W12312315 @default.
- W2034120777 cites W1823288226 @default.
- W2034120777 cites W1970650917 @default.
- W2034120777 cites W1971335607 @default.
- W2034120777 cites W1977536497 @default.
- W2034120777 cites W1987213013 @default.
- W2034120777 cites W1987853147 @default.
- W2034120777 cites W1989312844 @default.
- W2034120777 cites W1993570389 @default.
- W2034120777 cites W1995022664 @default.
- W2034120777 cites W1996522179 @default.
- W2034120777 cites W1999191285 @default.
- W2034120777 cites W2003795585 @default.
- W2034120777 cites W2008842970 @default.
- W2034120777 cites W2009382824 @default.
- W2034120777 cites W2019057293 @default.
- W2034120777 cites W2025242143 @default.
- W2034120777 cites W2038638713 @default.
- W2034120777 cites W2039452867 @default.
- W2034120777 cites W2039841798 @default.
- W2034120777 cites W2044635335 @default.
- W2034120777 cites W2046207683 @default.
- W2034120777 cites W2049026112 @default.
- W2034120777 cites W2053986756 @default.
- W2034120777 cites W2056543772 @default.
- W2034120777 cites W2061582510 @default.
- W2034120777 cites W2065247158 @default.
- W2034120777 cites W2067598924 @default.
- W2034120777 cites W2068933804 @default.
- W2034120777 cites W2069223773 @default.
- W2034120777 cites W2075188557 @default.
- W2034120777 cites W2077536394 @default.
- W2034120777 cites W2078123674 @default.
- W2034120777 cites W2081641246 @default.
- W2034120777 cites W2086916208 @default.
- W2034120777 cites W2087570063 @default.
- W2034120777 cites W2089603504 @default.
- W2034120777 cites W2089865016 @default.
- W2034120777 cites W2091706010 @default.
- W2034120777 cites W2093644197 @default.
- W2034120777 cites W2093802267 @default.
- W2034120777 cites W2097072725 @default.
- W2034120777 cites W2104289410 @default.
- W2034120777 cites W2105668062 @default.
- W2034120777 cites W2110490608 @default.
- W2034120777 cites W2123838494 @default.
- W2034120777 cites W2135476883 @default.
- W2034120777 cites W2137728343 @default.
- W2034120777 cites W2139077218 @default.
- W2034120777 cites W2139160718 @default.
- W2034120777 cites W2141474275 @default.
- W2034120777 cites W2156794442 @default.
- W2034120777 cites W2161506582 @default.
- W2034120777 cites W2166611436 @default.
- W2034120777 cites W2178456244 @default.
- W2034120777 cites W2333884926 @default.
- W2034120777 cites W2349550891 @default.
- W2034120777 cites W2622371525 @default.
- W2034120777 cites W73166725 @default.
- W2034120777 doi "https://doi.org/10.1016/j.bcp.2013.10.025" @default.
- W2034120777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24231507" @default.
- W2034120777 hasPublicationYear "2014" @default.
- W2034120777 type Work @default.
- W2034120777 sameAs 2034120777 @default.
- W2034120777 citedByCount "45" @default.
- W2034120777 countsByYear W20341207772014 @default.
- W2034120777 countsByYear W20341207772015 @default.
- W2034120777 countsByYear W20341207772016 @default.
- W2034120777 countsByYear W20341207772017 @default.
- W2034120777 countsByYear W20341207772018 @default.
- W2034120777 countsByYear W20341207772019 @default.
- W2034120777 countsByYear W20341207772020 @default.
- W2034120777 countsByYear W20341207772021 @default.
- W2034120777 countsByYear W20341207772022 @default.
- W2034120777 countsByYear W20341207772023 @default.
- W2034120777 crossrefType "journal-article" @default.
- W2034120777 hasAuthorship W2034120777A5006197653 @default.
- W2034120777 hasAuthorship W2034120777A5052981792 @default.
- W2034120777 hasAuthorship W2034120777A5062304427 @default.
- W2034120777 hasAuthorship W2034120777A5062826138 @default.
- W2034120777 hasAuthorship W2034120777A5071993355 @default.
- W2034120777 hasAuthorship W2034120777A5086545510 @default.
- W2034120777 hasAuthorship W2034120777A5087702568 @default.
- W2034120777 hasConcept C104317684 @default.
- W2034120777 hasConcept C109316439 @default.
- W2034120777 hasConcept C150194340 @default.