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• W2034121834 abstract "<i>Aim:</i> Our aim was to compare the interobserver variability between the 1998 WHO/ISUP and 1973 WHO classifications. <i>Methods:</i> 258 consecutive papillary urothelial carcinomas were reviewed by two pathologists and assigned a tumor grade according to the 1973 WHO and 1998 WHO/ISUP without the knowledge of primary diagnosis and clinical follow-up. All cases were also histologically staged by the two pathologists separately as follows: pTa (noninvasive), pT1 (lamina propria invasion only), pT2 (muscularis propria invasion). Findings of both pathologists and degree of agreement were compared statistically by using Pearson’s χ² test and ĸ statistics respectively. A ĸ value of 0.21–0.40 is accepted as fair, 0.41–0.60 moderate and 0.61–0.80 substantial agreement. <i>Results:</i> Regardless of the pathologist, tumor grades of two classifications correlated to each other and the pathological stage (p < 0.05). Overall degree of agreement between pathologists was higher in the 1998 WHO/ISUP (ĸ 0.59) than the 1973 WHO (ĸ 0.41), but both were still moderate. Papillary urothelial neoplasia with low malignant potential was the group of 1998 WHO/ISUP that showed the lowest degree of agreement and if excluded, interobserver variability of the 1998 WHO/ISUP decreased significantly (ĸ 0.84). <i>Conclusion:</i> The diagnosis of papillary urothelial neoplasia with low malignant potential and the criteria that differentiates it from low-grade carcinomas needs improvement in order to compare the different studies and therapies and to provide more accurate information for management." @default.
• W2034121834 created "2016-06-24" @default.
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• W2034121834 date "2007-01-01" @default.
• W2034121834 modified "2023-10-18" @default.
• W2034121834 title "Comparison of 1998 WHO/ISUP and 1973 WHO Classifications for Interobserver Variability in Grading of Papillary Urothelial Neoplasms of the Bladder" @default.
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• W2034121834 doi "https://doi.org/10.1159/000100839" @default.
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