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- W2034122364 abstract "Marek's disease virus (MDV), a herpesvirus of avian origin, is being examined for suitability as a vector for expressing foreign genes. We observed that plasmids encoding the LacZ gene of E. coli under the control of either the herpes simplex virus alpha 4 immediate-early promoter or the cytomegalovirus major immediate-early promoter inhibited MDV plaque formation. Plaque numbers were decreased by one-third, and transient expression of the beta-galactosidase reporter gene was increased by up to 6-fold, when the plasmids were linearized. Sequences associated with the heterologous promoter were identified as being responsible for inhibiting MDV replication." @default.
- W2034122364 created "2016-06-24" @default.
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- W2034122364 date "1992-11-01" @default.
- W2034122364 modified "2023-09-27" @default.
- W2034122364 title "Plasmid-associated effects on test gene expression and Marek's disease virus plaque formation during recombination trials" @default.
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- W2034122364 doi "https://doi.org/10.1016/0166-0934(92)90068-o" @default.
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